Multicentre study on inflammatory skin diseases from The International Confocal Working Group: specific confocal microscopy features and an algorithmic method of diagnosis

Marco Ardigò, Caterina Longo, Salvador González, Marina Agozzino, Marina Agozzino, A. Di Stefani, Marie Jeanne Gerittsen, Melissa Gill, Rainer Hofmann-Wellenhof, Mitchell Kline, Joseph Malvehy, Nuno Menezes, E. Moscarella, Elvira Moscarella, Susanna Puig, Babar Rao, Babar Rao, S. Segura, Peter Soyer, Ignazio StanganelliIgnazio Stanganelli, M. Venturini

Research output: Contribution to journalArticlepeer-review

Abstract

Background: The real value of reflectance confocal microscopy (RCM) for the evaluation of inflammatory skin conditions remains unclear. A project on RCM for inflammatory skin diseases involving international centres was designed by a coordinating centre and executed under the supervision of the International Confocal Working Group. Objectives: To identify specific confocal features useful for distinction between the three main groups of superficial inflammatory skin diseases. Methods: Nineteen different RCM features were evaluated in a total of 155 lesions, diagnosed as spongiotic (45), interface (52) or psoriasiform (58) dermatitis, collected by a consortium of 19 different centres. Results: Univariate and multivariate analysis identified RCM descriptors for the three main superficial inflammatory disease groups. Later, a multivariate method was employed to define a scoring system to be applied on an algorithmic method of analysis for fast clinical application. Conclusions: Our preliminary evaluation supports the use of RCM for the identification of confocal patterns consistent with the major features of the diagnostic groups of inflammatory skin diseases. Moreover, an efficient multivariate method for clinical in vivo RCM diagnosis using a tree decision diagram has been established.

Original languageEnglish
Pages (from-to)364-374
Number of pages11
JournalBritish Journal of Dermatology
Volume175
Issue number2
DOIs
Publication statusPublished - 2016

ASJC Scopus subject areas

  • Dermatology

Fingerprint Dive into the research topics of 'Multicentre study on inflammatory skin diseases from The International Confocal Working Group: specific confocal microscopy features and an algorithmic method of diagnosis'. Together they form a unique fingerprint.

Cite this