Multicentric breast cancer with heterogeneous histopathology: A multidisciplinary review

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Multiple synchronous (multifocal or multicentric) ipsilateral breast cancers with heterogeneous histopathology are a rare clinical occurrence, however, their incidence is increasing due to the use of MRI for breast cancer screening and staging. Some studies have demonstrated poorer clinical outcomes for this pattern of breast cancer, but there is no evidence to guide clinical practice. In this multidisciplinary review, we reflect on pathology and molecular characteristics, imaging findings, surgical management including conservation and reconstructive options and approach to the axilla, and the role of chemotherapy and radiotherapy. Multidisciplinary discussions appear decisive in planning an appropriate surgical choice and defining the correct systemic treatment tailored to each clinical condition.

Original languageEnglish
Pages (from-to)395-412
Number of pages18
JournalFuture Oncology
Issue number8
Publication statusPublished - Feb 6 2020


  • breast cancer
  • breast cancer histotypes
  • diagnosis
  • lobular carcinoma
  • multicentric cancer
  • multidisciplinary team
  • multifocal cancer
  • prognosis
  • surgical management

ASJC Scopus subject areas

  • Oncology
  • Cancer Research


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