Multicentric giant cell tumor with viral-like inclusions associated with Paget's disease of bone: A case treated by steroid therapy

Annarosaria De Chiara; Gaetano Apice; Flavio Fazioli; Pasqualina Silvestro; Guglielmo Carone; Alfredo Manco

Multicentric giant cell tumor with viral-like inclusions associated with Paget's disease of bone: A case treated by steroid therapy

Annarosaria De Chiara, Gaetano Apice, Flavio Fazioli, Pasqualina Silvestro, Guglielmo Carone, Alfredo Manco

Istituto Nazionale Tumori Fondazione G. Pascale

Research output: Contribution to journal › Article › peer-review

Abstract

We report a case of giant cell tumor of bone (GCTB) associated with Paget's disease unsuccessfully treated with radiotherapy for some years but dramatically reduced in size with high dose of dexamethasone within few days. An ultrastructural study showed intranuclear virus-like inclusions in the multinucleated giant cells. The patient was then switched to prednisone plus diclofenac and he is still in almost complete remission after two years. The patient was from Avellino area, a small town in Southern Italy.

Original language	English
Pages (from-to)	317-320
Number of pages	4
Journal	Oncology Reports
Volume	5
Issue number	2
Publication status	Published - 1998

Keywords

Bone
Giant cell tumor
Paget
Steroid therapy
Viral-like inclusions

ASJC Scopus subject areas

Cancer Research
Oncology

Cite this

Multicentric giant cell tumor with viral-like inclusions associated with Paget's disease of bone : A case treated by steroid therapy. / De Chiara, Annarosaria ; Apice, Gaetano ; Fazioli, Flavio; Silvestro, Pasqualina; Carone, Guglielmo; Manco, Alfredo.

In: Oncology Reports, Vol. 5, No. 2, 1998, p. 317-320.

Research output: Contribution to journal › Article › peer-review

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AU - Carone, Guglielmo

AU - Manco, Alfredo

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AB - We report a case of giant cell tumor of bone (GCTB) associated with Paget's disease unsuccessfully treated with radiotherapy for some years but dramatically reduced in size with high dose of dexamethasone within few days. An ultrastructural study showed intranuclear virus-like inclusions in the multinucleated giant cells. The patient was then switched to prednisone plus diclofenac and he is still in almost complete remission after two years. The patient was from Avellino area, a small town in Southern Italy.

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KW - Viral-like inclusions

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Multicentric giant cell tumor with viral-like inclusions associated with Paget's disease of bone: A case treated by steroid therapy

Abstract

Keywords

ASJC Scopus subject areas

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