Multicentric giant cell tumor with viral-like inclusions associated with Paget's disease of bone: A case treated by steroid therapy

Annarosaria De Chiara, Gaetano Apice, Flavio Fazioli, Pasqualina Silvestro, Guglielmo Carone, Alfredo Manco

Research output: Contribution to journalArticlepeer-review

Abstract

We report a case of giant cell tumor of bone (GCTB) associated with Paget's disease unsuccessfully treated with radiotherapy for some years but dramatically reduced in size with high dose of dexamethasone within few days. An ultrastructural study showed intranuclear virus-like inclusions in the multinucleated giant cells. The patient was then switched to prednisone plus diclofenac and he is still in almost complete remission after two years. The patient was from Avellino area, a small town in Southern Italy.

Original languageEnglish
Pages (from-to)317-320
Number of pages4
JournalOncology Reports
Volume5
Issue number2
Publication statusPublished - 1998

Keywords

  • Bone
  • Giant cell tumor
  • Paget
  • Steroid therapy
  • Viral-like inclusions

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

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