Multicentric glioma: Our experience in 25 patients and critical review of the literature

Maurizio Salvati, Emanuela Caroli, Epimenio Ramundo Orlando, Alessandro Frati, Spartaco Artizzu, Luigi Ferrante

Research output: Contribution to journalArticlepeer-review


Multicentric gliomas are interesting and well-recognised entities with a yet unknown rate of occurrence. Single cases or small series are reported in the literature accessible to us, and we think this is the first large series describing true multicentric gliomas. We reviewed 25 patients selected according to the criteria defined by Batzdorf and Malamud. Multicentricity was found in 2% of patients with malignant gliomas. Longer survival was observed in patients who underwent surgical excision of the multicentric lesions. Multicentric tumours are rare clinical entities. Our data suggest that they should be surgically removed whenever possible, and histopathologic examination of the lesions is always advisable if they are located in sites inaccessible to surgery. Stereotactic biopsy represents a safe and satisfactory method for achieving sure diagnosis.

Original languageEnglish
Pages (from-to)275-279
Number of pages5
JournalNeurosurgical Review
Issue number4
Publication statusPublished - Oct 2003


  • Glioma
  • Multicentric glioma
  • Multiple cerebral lesions
  • Stereotactic biopsy

ASJC Scopus subject areas

  • Clinical Neurology
  • Surgery


Dive into the research topics of 'Multicentric glioma: Our experience in 25 patients and critical review of the literature'. Together they form a unique fingerprint.

Cite this