Multicompartment vectors as novel drug delivery systems: Selective activation of Tγδ lymphocytes after zoledronic acid delivery

Chiara Agrati, Carlotta Marianecci, Simona Sennato, Maria Carafa, Veronica Bordoni, Eleonora Cimini, Massimo Tempestilli, Leopoldo P. Pucillo, Federica Turchi, Federico Martini, Giorgio Borioni, Federico Bordi

Research output: Contribution to journalArticlepeer-review

Abstract

Multicompartment nanoscopic carriers can be easily assembled by inducing the aggregation of anionic "hybrid" niosomes by means of cationic biocompatible polyelectrolytes. The resulting vesicle clusters, whose size and overall net charge can be easily controlled by varying the polyelectrolyte-to-particle charge ratio, show an interesting potential for multidrug delivery. In this article we provide strong evidence for their effective use in vitro as multicompartment vectors selectively directed toward monocyte/macrophage cells, showing that the monocyte/macrophage-mediated activation of Tγδ lymphocytes induced by zoledronic acid is enhanced by a factor 103 when the zoledronic acid is intracellularly delivered through these carriers. Furthermore, the multicompartment ε-polylysine niosome clusters, with their intrinsic selectivity toward macrophages, appear particularly suitable for implementing therapeutic strategies against chronically infected macrophages. From the Clinical Editor: ε-polylysine niosome clusters, with their intrinsic selectivity toward macrophages, offer the potential for multidrug delivery. The effectiveness of aminobisphosphonate zoledronate is demonstrated to enhance the recruitment of Tγδ lymphocytes by macrophages by 2 orders of magnitude, suggesting a new therapeutic strategy for addressing pathologies featuring chronically infected macrophages.

Original languageEnglish
Pages (from-to)153-161
Number of pages9
JournalNanomedicine: Nanotechnology, Biology, and Medicine
Volume7
Issue number2
DOIs
Publication statusPublished - Apr 2011

Keywords

  • HIV therapy
  • Nanovectors
  • Polyelectrolyte-niosome complexes
  • Tγδ lymphocytes
  • Zoledronic acid

ASJC Scopus subject areas

  • Molecular Medicine
  • Bioengineering
  • Biomedical Engineering
  • Materials Science(all)
  • Medicine (miscellaneous)
  • Pharmaceutical Science

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