Abstract
Multicompartment nanoscopic carriers can be easily assembled by inducing the aggregation of anionic "hybrid" niosomes by means of cationic biocompatible polyelectrolytes. The resulting vesicle clusters, whose size and overall net charge can be easily controlled by varying the polyelectrolyte-to-particle charge ratio, show an interesting potential for multidrug delivery. In this article we provide strong evidence for their effective use in vitro as multicompartment vectors selectively directed toward monocyte/macrophage cells, showing that the monocyte/macrophage-mediated activation of Tγδ lymphocytes induced by zoledronic acid is enhanced by a factor 103 when the zoledronic acid is intracellularly delivered through these carriers. Furthermore, the multicompartment ε-polylysine niosome clusters, with their intrinsic selectivity toward macrophages, appear particularly suitable for implementing therapeutic strategies against chronically infected macrophages. From the Clinical Editor: ε-polylysine niosome clusters, with their intrinsic selectivity toward macrophages, offer the potential for multidrug delivery. The effectiveness of aminobisphosphonate zoledronate is demonstrated to enhance the recruitment of Tγδ lymphocytes by macrophages by 2 orders of magnitude, suggesting a new therapeutic strategy for addressing pathologies featuring chronically infected macrophages.
| Original language | English |
|---|---|
| Pages (from-to) | 153-161 |
| Number of pages | 9 |
| Journal | Nanomedicine: Nanotechnology, Biology, and Medicine |
| Volume | 7 |
| Issue number | 2 |
| DOIs | |
| Publication status | Published - Apr 2011 |
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Keywords
- HIV therapy
- Nanovectors
- Polyelectrolyte-niosome complexes
- Tγδ lymphocytes
- Zoledronic acid
ASJC Scopus subject areas
- Molecular Medicine
- Bioengineering
- Biomedical Engineering
- Materials Science(all)
- Medicine (miscellaneous)
- Pharmaceutical Science
Cite this
Multicompartment vectors as novel drug delivery systems : Selective activation of Tγδ lymphocytes after zoledronic acid delivery. / Agrati, Chiara; Marianecci, Carlotta; Sennato, Simona; Carafa, Maria; Bordoni, Veronica; Cimini, Eleonora; Tempestilli, Massimo; Pucillo, Leopoldo P.; Turchi, Federica; Martini, Federico; Borioni, Giorgio; Bordi, Federico.
In: Nanomedicine: Nanotechnology, Biology, and Medicine, Vol. 7, No. 2, 04.2011, p. 153-161.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Multicompartment vectors as novel drug delivery systems
T2 - Selective activation of Tγδ lymphocytes after zoledronic acid delivery
AU - Agrati, Chiara
AU - Marianecci, Carlotta
AU - Sennato, Simona
AU - Carafa, Maria
AU - Bordoni, Veronica
AU - Cimini, Eleonora
AU - Tempestilli, Massimo
AU - Pucillo, Leopoldo P.
AU - Turchi, Federica
AU - Martini, Federico
AU - Borioni, Giorgio
AU - Bordi, Federico
PY - 2011/4
Y1 - 2011/4
N2 - Multicompartment nanoscopic carriers can be easily assembled by inducing the aggregation of anionic "hybrid" niosomes by means of cationic biocompatible polyelectrolytes. The resulting vesicle clusters, whose size and overall net charge can be easily controlled by varying the polyelectrolyte-to-particle charge ratio, show an interesting potential for multidrug delivery. In this article we provide strong evidence for their effective use in vitro as multicompartment vectors selectively directed toward monocyte/macrophage cells, showing that the monocyte/macrophage-mediated activation of Tγδ lymphocytes induced by zoledronic acid is enhanced by a factor 103 when the zoledronic acid is intracellularly delivered through these carriers. Furthermore, the multicompartment ε-polylysine niosome clusters, with their intrinsic selectivity toward macrophages, appear particularly suitable for implementing therapeutic strategies against chronically infected macrophages. From the Clinical Editor: ε-polylysine niosome clusters, with their intrinsic selectivity toward macrophages, offer the potential for multidrug delivery. The effectiveness of aminobisphosphonate zoledronate is demonstrated to enhance the recruitment of Tγδ lymphocytes by macrophages by 2 orders of magnitude, suggesting a new therapeutic strategy for addressing pathologies featuring chronically infected macrophages.
AB - Multicompartment nanoscopic carriers can be easily assembled by inducing the aggregation of anionic "hybrid" niosomes by means of cationic biocompatible polyelectrolytes. The resulting vesicle clusters, whose size and overall net charge can be easily controlled by varying the polyelectrolyte-to-particle charge ratio, show an interesting potential for multidrug delivery. In this article we provide strong evidence for their effective use in vitro as multicompartment vectors selectively directed toward monocyte/macrophage cells, showing that the monocyte/macrophage-mediated activation of Tγδ lymphocytes induced by zoledronic acid is enhanced by a factor 103 when the zoledronic acid is intracellularly delivered through these carriers. Furthermore, the multicompartment ε-polylysine niosome clusters, with their intrinsic selectivity toward macrophages, appear particularly suitable for implementing therapeutic strategies against chronically infected macrophages. From the Clinical Editor: ε-polylysine niosome clusters, with their intrinsic selectivity toward macrophages, offer the potential for multidrug delivery. The effectiveness of aminobisphosphonate zoledronate is demonstrated to enhance the recruitment of Tγδ lymphocytes by macrophages by 2 orders of magnitude, suggesting a new therapeutic strategy for addressing pathologies featuring chronically infected macrophages.
KW - HIV therapy
KW - Nanovectors
KW - Polyelectrolyte-niosome complexes
KW - Tγδ lymphocytes
KW - Zoledronic acid
UR - http://www.scopus.com/inward/record.url?scp=79952764490&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=79952764490&partnerID=8YFLogxK
U2 - 10.1016/j.nano.2010.10.003
DO - 10.1016/j.nano.2010.10.003
M3 - Article
C2 - 21034859
AN - SCOPUS:79952764490
VL - 7
SP - 153
EP - 161
JO - Nanomedicine: Nanotechnology, Biology, and Medicine
JF - Nanomedicine: Nanotechnology, Biology, and Medicine
SN - 1549-9634
IS - 2
ER -