Multicyclic dose-intensive chemotherapy with circulating progenitor cell support for high-risk primary breast cancer

M. Danova, C. Perotti, O. Mora, C. Lucotti, L. Torretta, G. Comolli, A. Riccardi, L. Salvaneschi, E. Ascari

Research output: Contribution to journalArticlepeer-review

Abstract

The feasibility and safety of the administration of multiple cycles of dose-intensive chemotherapy (CT) supported with repeated reinfusions of circulating progenitor cells (CPCs) were evaluated in a prospective study of adjuvant initial therapy of poor-prognosis breast cancer. Eighteen patients with resectable breast cancer involving ≤10 axillary nodes or ≤5 axillary nodes and negativity of the estrogen receptor status received a cycle of standard FEC regimen (5-FU 600 mg/m2, epirubicin 60 mg/m2, CTX 600 mg/m2, i.v. on day 1) followed by G-CSF as CPC mobilization technique. Collected CPCs were fractionated and reinfused, with G-CSF, after each of the 4 subsequent cycles of high-dose FEC (HD-FEC) (5-FU 750 mg/m2, epirubicin 120 mg/m2, CTX 3 g/m2, i.v.) planned at 21 day intervals. The median numbers of CD34+ cells and CFU-GM collected (with one or two leukaphereses per patient) were 9.7x106/kg (range: 2.5-22.9) and 9.9x104/kg (range: 1.9-27.3), respectively, and day 9 was the median first day of procedure (range: 8-12) after FEC. All patients received the 4 courses of HD-FEC (for a total of 72 cycles). Hemopoietic recovery was rapid after each cycle and there was no treatment-related delays in CT administration. Mucositis was the major non- hematological toxicity. There were 2, 3, 7 and 9 episodes of WHO grade 3/4 mucositis in cycles 1, 2, 3 and 4, respectively. These severe episodes lasted a median of 4 days (range: 2-6) but no patient required parenteral nutrition. The mean ± SD total hospital stay lasted 10±2 days. The delivery of 4 cycles of dose-intensive FEC CT supported by CPCs (mobilized with a single course of standard-dose FEC + G-CSF) is feasible and safe. It could represent an effective alternative strategy to other more aggressive programs for the adjuvant therapy of high-risk early breast cancer.

Original languageEnglish
Pages (from-to)427-429
Number of pages3
JournalOncology Reports
Volume5
Issue number2
Publication statusPublished - 1998

Keywords

  • Adjuvant therapy
  • Breast cancer
  • Circulating progenitor cells
  • G-CSF
  • Multicyclic dose-intensive chemotherapy

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

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