Multicystic peritoneal mesothelioma treated by surgical cytoreduction and hyperthermic intra-peritoneal chemotherapy (HIPEC)

D. Baratti, S. Kusamura, A. Sironi, A. Cabras, L. Fumagalli, B. Laterza, Marcello Deraco

Research output: Contribution to journalArticle


Background: Multicystic peritoneal mesothelioma (MPM) is an extremely uncommon lesion with uncertain malignant potential. Multiple recurrences after surgical interventions and transition to aggressive malignancies have been reported. Here, we review our experience with cytoreduction and hyperthermic intraperitoneal chemotherapy (HIPEC) in the management of MPM. Patients and Methods: Five women with MPM underwent 6 procedures of cytoreduction and close-abdomen HIPEC with cisplatin and doxorubicin. Three patients had recurrent disease after 1, 2 and 4 previous debulkings, respectively. Results: Optimal cytoreduction (residual tumor nodules ≤2.5 mm) was performed in all the procedures. One grade 4 postoperative complication (NCI/CTCAE v. 3.0) and no operative mortality occurred. Median follow-up was 31 months (range 3-102). MPM recurred in two patients: one is presently disease-free after a second cytoreduction with HIPEC and the other is alive with minimal stable disease. Conclusion: Definitive eradication by means of cytoreduction and HIPEC seems a safe and effective therapeutic option for MPM.

Original languageEnglish
Pages (from-to)153-158
Number of pages6
JournalIn Vivo
Issue number1
Publication statusPublished - Jan 2008



  • Hyperthermic intra-peritoneal chemotherapy
  • Multicystic peritoneal mesothelioma
  • Peritonectomy

ASJC Scopus subject areas

  • Medicine(all)

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