Multidisciplinary approach to osteosarcoma

Alessio Biazzo, Massimiliano De Paolis

Research output: Contribution to journalReview article

15 Citations (Scopus)

Abstract

Osteosarcoma is a malignant bone tumor composed of mesenchymal cells producing osteoid and immature bone. Osteosarcoma is the most frequent primary malignant bone tumor, if we excluded myeloma, a haematologic disease. The incidence of osteosarcoma is 2-3/million/year, but is higher in adolescence, in which the annual incidence peaks at 8-11/million/year at 15-19 years of age. Local pain, followed by localized swelling and limitation of joint movement, are the typical signs and symptoms. Correct diagnosis can be achieved through a correct approach to the disease and the combination of clinical and radiographic aspects. The final step to confirm the diagnosis is the biopsy. Computer Tomography of the chest and Positron- Emission Tomography are mandatory to complete the staging, which is performed according the Musculoskeletal Tumor Society staging system. A multidisciplinary approach is needed both to get to a correct diagnosis (orthopaedic surgeon, radiologist and histopathologist) and to perform definitive treatment. Multidisciplinary approach should be performed in reference centers able to provide access to the full spectrum of care and where orthopaedic surgeon, oncologist, histopathologist, radiologist and radiotherapist can cooperate. The management of osteosarcoma is based primarily on neo-Adjuvant and adjuvant chemotherapy and surgical resection; radiotherapy is not effective as osteosarcomas are relatively radioresistant. Prognostic factors include metastases at presentation, histologic response to induction chemotherapy, the site of the primary tumor (with axial lesions having an inferior outcome), serum lactate dehydrogenase and alkaline phosphatase levels.

Original languageEnglish
Pages (from-to)690-698
Number of pages9
JournalActa Orthopaedica Belgica
Volume82
Issue number4
Publication statusPublished - 2017

Fingerprint

Osteosarcoma
Bone and Bones
Neoplasms
Induction Chemotherapy
Hematologic Diseases
Neoplasm Staging
Incidence
Adjuvant Chemotherapy
L-Lactate Dehydrogenase
Positron-Emission Tomography
Signs and Symptoms
Alkaline Phosphatase
Radiotherapy
Thorax
Joints
Tomography
Neoplasm Metastasis
Biopsy
Pain
Serum

Keywords

  • Chemotherapy
  • Multidisciplinary approach
  • Osteosarcoma
  • Primary bone tumor
  • Treatment

ASJC Scopus subject areas

  • Medicine(all)
  • Orthopedics and Sports Medicine

Cite this

Biazzo, A., & De Paolis, M. (2017). Multidisciplinary approach to osteosarcoma. Acta Orthopaedica Belgica, 82(4), 690-698.

Multidisciplinary approach to osteosarcoma. / Biazzo, Alessio; De Paolis, Massimiliano.

In: Acta Orthopaedica Belgica, Vol. 82, No. 4, 2017, p. 690-698.

Research output: Contribution to journalReview article

Biazzo, A & De Paolis, M 2017, 'Multidisciplinary approach to osteosarcoma', Acta Orthopaedica Belgica, vol. 82, no. 4, pp. 690-698.
Biazzo A, De Paolis M. Multidisciplinary approach to osteosarcoma. Acta Orthopaedica Belgica. 2017;82(4):690-698.
Biazzo, Alessio ; De Paolis, Massimiliano. / Multidisciplinary approach to osteosarcoma. In: Acta Orthopaedica Belgica. 2017 ; Vol. 82, No. 4. pp. 690-698.
@article{3257bcf599de49578cc036135d4eaf2b,
title = "Multidisciplinary approach to osteosarcoma",
abstract = "Osteosarcoma is a malignant bone tumor composed of mesenchymal cells producing osteoid and immature bone. Osteosarcoma is the most frequent primary malignant bone tumor, if we excluded myeloma, a haematologic disease. The incidence of osteosarcoma is 2-3/million/year, but is higher in adolescence, in which the annual incidence peaks at 8-11/million/year at 15-19 years of age. Local pain, followed by localized swelling and limitation of joint movement, are the typical signs and symptoms. Correct diagnosis can be achieved through a correct approach to the disease and the combination of clinical and radiographic aspects. The final step to confirm the diagnosis is the biopsy. Computer Tomography of the chest and Positron- Emission Tomography are mandatory to complete the staging, which is performed according the Musculoskeletal Tumor Society staging system. A multidisciplinary approach is needed both to get to a correct diagnosis (orthopaedic surgeon, radiologist and histopathologist) and to perform definitive treatment. Multidisciplinary approach should be performed in reference centers able to provide access to the full spectrum of care and where orthopaedic surgeon, oncologist, histopathologist, radiologist and radiotherapist can cooperate. The management of osteosarcoma is based primarily on neo-Adjuvant and adjuvant chemotherapy and surgical resection; radiotherapy is not effective as osteosarcomas are relatively radioresistant. Prognostic factors include metastases at presentation, histologic response to induction chemotherapy, the site of the primary tumor (with axial lesions having an inferior outcome), serum lactate dehydrogenase and alkaline phosphatase levels.",
keywords = "Chemotherapy, Multidisciplinary approach, Osteosarcoma, Primary bone tumor, Treatment",
author = "Alessio Biazzo and {De Paolis}, Massimiliano",
year = "2017",
language = "English",
volume = "82",
pages = "690--698",
journal = "Acta Orthopaedica Belgica",
issn = "0001-6462",
publisher = "ARSMB-KVBMG",
number = "4",

}

TY - JOUR

T1 - Multidisciplinary approach to osteosarcoma

AU - Biazzo, Alessio

AU - De Paolis, Massimiliano

PY - 2017

Y1 - 2017

N2 - Osteosarcoma is a malignant bone tumor composed of mesenchymal cells producing osteoid and immature bone. Osteosarcoma is the most frequent primary malignant bone tumor, if we excluded myeloma, a haematologic disease. The incidence of osteosarcoma is 2-3/million/year, but is higher in adolescence, in which the annual incidence peaks at 8-11/million/year at 15-19 years of age. Local pain, followed by localized swelling and limitation of joint movement, are the typical signs and symptoms. Correct diagnosis can be achieved through a correct approach to the disease and the combination of clinical and radiographic aspects. The final step to confirm the diagnosis is the biopsy. Computer Tomography of the chest and Positron- Emission Tomography are mandatory to complete the staging, which is performed according the Musculoskeletal Tumor Society staging system. A multidisciplinary approach is needed both to get to a correct diagnosis (orthopaedic surgeon, radiologist and histopathologist) and to perform definitive treatment. Multidisciplinary approach should be performed in reference centers able to provide access to the full spectrum of care and where orthopaedic surgeon, oncologist, histopathologist, radiologist and radiotherapist can cooperate. The management of osteosarcoma is based primarily on neo-Adjuvant and adjuvant chemotherapy and surgical resection; radiotherapy is not effective as osteosarcomas are relatively radioresistant. Prognostic factors include metastases at presentation, histologic response to induction chemotherapy, the site of the primary tumor (with axial lesions having an inferior outcome), serum lactate dehydrogenase and alkaline phosphatase levels.

AB - Osteosarcoma is a malignant bone tumor composed of mesenchymal cells producing osteoid and immature bone. Osteosarcoma is the most frequent primary malignant bone tumor, if we excluded myeloma, a haematologic disease. The incidence of osteosarcoma is 2-3/million/year, but is higher in adolescence, in which the annual incidence peaks at 8-11/million/year at 15-19 years of age. Local pain, followed by localized swelling and limitation of joint movement, are the typical signs and symptoms. Correct diagnosis can be achieved through a correct approach to the disease and the combination of clinical and radiographic aspects. The final step to confirm the diagnosis is the biopsy. Computer Tomography of the chest and Positron- Emission Tomography are mandatory to complete the staging, which is performed according the Musculoskeletal Tumor Society staging system. A multidisciplinary approach is needed both to get to a correct diagnosis (orthopaedic surgeon, radiologist and histopathologist) and to perform definitive treatment. Multidisciplinary approach should be performed in reference centers able to provide access to the full spectrum of care and where orthopaedic surgeon, oncologist, histopathologist, radiologist and radiotherapist can cooperate. The management of osteosarcoma is based primarily on neo-Adjuvant and adjuvant chemotherapy and surgical resection; radiotherapy is not effective as osteosarcomas are relatively radioresistant. Prognostic factors include metastases at presentation, histologic response to induction chemotherapy, the site of the primary tumor (with axial lesions having an inferior outcome), serum lactate dehydrogenase and alkaline phosphatase levels.

KW - Chemotherapy

KW - Multidisciplinary approach

KW - Osteosarcoma

KW - Primary bone tumor

KW - Treatment

UR - http://www.scopus.com/inward/record.url?scp=85019094496&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85019094496&partnerID=8YFLogxK

M3 - Review article

VL - 82

SP - 690

EP - 698

JO - Acta Orthopaedica Belgica

JF - Acta Orthopaedica Belgica

SN - 0001-6462

IS - 4

ER -