Multidisciplinary management of recurrent and metastatic hepatocellular carcinoma after resection: an international expert consensus

MDT of West China Hospital*

Research output: Contribution to journalReview article

Abstract

Hepatocellular carcinoma (HCC) is the sixth-most common cancer and the third leading cause of cancer-related death in the world. However, 40-70% patients eventually suffer from postoperative recurrence within 5 years. HCC recurrence after surgery severely affects prognosis of the patients. Nevertheless, there is an opportunity to improve patients' prognosis if doctors and researchers can recognize the importance of a standardized perioperative management and study it in clinical and pre-clinical settings. Hence, based on our own experience and published studies from other researchers, we develop this consensus regarding multidisciplinary management of locally recurrent and metastatic hepatocellular carcinoma after resection. This consensus consists of the entire course of recurrent hepatocellular carcinoma (RHCC) management, including prediction of recurrence, prevention, diagnosis, treatment and surveillance of RHCC. Consensus recommendations are presented with grades of evidences (Ia, Ib, IIa, IIb, III and IV), and strength of recommendations (A, B, C, D and E). We also develop a decision-making path for RHCC treatment, which can intuitively demonstrate the management for RHCC. It is hoped that we may make some effort to standardize the management of RHCC and ultimately understand how to improve outcomes.

Original languageEnglish
Pages (from-to)353-371
Number of pages19
JournalHepatobiliary surgery and nutrition
Volume7
Issue number5
DOIs
Publication statusPublished - Oct 2018

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Hepatocellular Carcinoma
Consensus
Recurrence
Research Personnel
Neoplasms
Decision Making
Therapeutics

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Multidisciplinary management of recurrent and metastatic hepatocellular carcinoma after resection : an international expert consensus. / MDT of West China Hospital*.

In: Hepatobiliary surgery and nutrition, Vol. 7, No. 5, 10.2018, p. 353-371.

Research output: Contribution to journalReview article

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title = "Multidisciplinary management of recurrent and metastatic hepatocellular carcinoma after resection: an international expert consensus",
abstract = "Hepatocellular carcinoma (HCC) is the sixth-most common cancer and the third leading cause of cancer-related death in the world. However, 40-70{\%} patients eventually suffer from postoperative recurrence within 5 years. HCC recurrence after surgery severely affects prognosis of the patients. Nevertheless, there is an opportunity to improve patients' prognosis if doctors and researchers can recognize the importance of a standardized perioperative management and study it in clinical and pre-clinical settings. Hence, based on our own experience and published studies from other researchers, we develop this consensus regarding multidisciplinary management of locally recurrent and metastatic hepatocellular carcinoma after resection. This consensus consists of the entire course of recurrent hepatocellular carcinoma (RHCC) management, including prediction of recurrence, prevention, diagnosis, treatment and surveillance of RHCC. Consensus recommendations are presented with grades of evidences (Ia, Ib, IIa, IIb, III and IV), and strength of recommendations (A, B, C, D and E). We also develop a decision-making path for RHCC treatment, which can intuitively demonstrate the management for RHCC. It is hoped that we may make some effort to standardize the management of RHCC and ultimately understand how to improve outcomes.",
author = "{MDT of West China Hospital*} and Tianfu Wen and Chen Jin and Antonio Facciorusso and Matteo Donadon and Ho-Seong Han and Yilei Mao and Chaoliu Dai and Shuqun Cheng and Bixiang Zhang and Baogang Peng and Shunda Du and Changjun Jia and Feng Xu and Jie Shi and Juxian Sun and Peng Zhu and Satoshi Nara and Millis, {J Michael}",
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T1 - Multidisciplinary management of recurrent and metastatic hepatocellular carcinoma after resection

T2 - an international expert consensus

AU - MDT of West China Hospital

AU - Wen, Tianfu

AU - Jin, Chen

AU - Facciorusso, Antonio

AU - Donadon, Matteo

AU - Han, Ho-Seong

AU - Mao, Yilei

AU - Dai, Chaoliu

AU - Cheng, Shuqun

AU - Zhang, Bixiang

AU - Peng, Baogang

AU - Du, Shunda

AU - Jia, Changjun

AU - Xu, Feng

AU - Shi, Jie

AU - Sun, Juxian

AU - Zhu, Peng

AU - Nara, Satoshi

AU - Millis, J Michael

PY - 2018/10

Y1 - 2018/10

N2 - Hepatocellular carcinoma (HCC) is the sixth-most common cancer and the third leading cause of cancer-related death in the world. However, 40-70% patients eventually suffer from postoperative recurrence within 5 years. HCC recurrence after surgery severely affects prognosis of the patients. Nevertheless, there is an opportunity to improve patients' prognosis if doctors and researchers can recognize the importance of a standardized perioperative management and study it in clinical and pre-clinical settings. Hence, based on our own experience and published studies from other researchers, we develop this consensus regarding multidisciplinary management of locally recurrent and metastatic hepatocellular carcinoma after resection. This consensus consists of the entire course of recurrent hepatocellular carcinoma (RHCC) management, including prediction of recurrence, prevention, diagnosis, treatment and surveillance of RHCC. Consensus recommendations are presented with grades of evidences (Ia, Ib, IIa, IIb, III and IV), and strength of recommendations (A, B, C, D and E). We also develop a decision-making path for RHCC treatment, which can intuitively demonstrate the management for RHCC. It is hoped that we may make some effort to standardize the management of RHCC and ultimately understand how to improve outcomes.

AB - Hepatocellular carcinoma (HCC) is the sixth-most common cancer and the third leading cause of cancer-related death in the world. However, 40-70% patients eventually suffer from postoperative recurrence within 5 years. HCC recurrence after surgery severely affects prognosis of the patients. Nevertheless, there is an opportunity to improve patients' prognosis if doctors and researchers can recognize the importance of a standardized perioperative management and study it in clinical and pre-clinical settings. Hence, based on our own experience and published studies from other researchers, we develop this consensus regarding multidisciplinary management of locally recurrent and metastatic hepatocellular carcinoma after resection. This consensus consists of the entire course of recurrent hepatocellular carcinoma (RHCC) management, including prediction of recurrence, prevention, diagnosis, treatment and surveillance of RHCC. Consensus recommendations are presented with grades of evidences (Ia, Ib, IIa, IIb, III and IV), and strength of recommendations (A, B, C, D and E). We also develop a decision-making path for RHCC treatment, which can intuitively demonstrate the management for RHCC. It is hoped that we may make some effort to standardize the management of RHCC and ultimately understand how to improve outcomes.

U2 - 10.21037/hbsn.2018.08.01

DO - 10.21037/hbsn.2018.08.01

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VL - 7

SP - 353

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JO - Hepatobiliary surgery and nutrition

JF - Hepatobiliary surgery and nutrition

SN - 2304-3881

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