Multidisciplinary management of retroperitoneal sarcoma: Diagnosis, prognostic factors and treatment

Fabio Carbone, Antonio Pizzolorusso, Giuseppe Di Lorenzo, Massimiliano Di Marzo, Lucia Cannella, Maria Luisa Barretta, Paolo Delrio, Salvatore Tafuto

Research output: Contribution to journalReview articlepeer-review

Abstract

Retroperitoneal sarcomas (RPS) are rare cancers whose management can be challenging due to various presentation patterns, multiple organ involvement, and a high local and distant recurrence rate. Histopathology and prognostic factors analysis are essential to predict the behaviour of the disease and plan the best therapeutic strategy. To date, surgery is still the main therapeutic option that guarantees a chance of cure from the primary disease. While chemotherapy and radiotherapy seem to be good options for controlling metastatic and recurrent irresectable disease, their role in the treatment of primary RPS remains unclear. This literature review aims to provide a comprehensive overview of the multidisciplinary aspects of RPS management in high-volume centres, summarising the diagnostic path, the prognostic factors, and the most suitable therapeutic options.

Original languageEnglish
Article number4016
JournalCancers
Volume13
Issue number16
DOIs
Publication statusPublished - Aug 2 2021

Keywords

  • Cancer
  • Literature review
  • Management
  • Multidisciplinary
  • Retroperitoneal sarcoma

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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