Multidisciplinary treatment of early stage endometrial cancer

S. C. Cecere, C. Pisano, A. Bamias, M. Di Napoli, S. Rossetti, G. Facchini, R. Tambaro, S. Pignata

Research output: Contribution to journalArticlepeer-review

Abstract

Endometrial cancer is a highly curable malignancy when it presents as uterine-confined disease, but the prognosis for metastatic or recurrent endometrial cancer is poor. For those patients which are diagnosed at an early stage, surgery alone may be adequate for cure and clinical outcome is often favorable, with approximately 80 % of cases surviving at 5 years. However, after primary diagnosis and treatment, roughly 20-30% of patients are expected to recur within the following 5 years. Adjuvant treatment for endometrial cancer is not yet clearly defined. FIGO Stage I-III endometrial cancer patients, usually undergo surgery and some of them are offered adjuvant treatment based on risk assessment. Grade, age, stage are considered all independent risk factors for recurrence. Radiotherapy (RT) has been considered the adjuvant treatment of choice for decades, being able to reduce local recurrence rate and improving progression free survival, but without any impact on overall survival. In the last two decades, a shift toward the use of systemic chemotherapy (CT) in addition or instead of radiation has occurred, although few prospective studies have been performed in this field.

Original languageEnglish
Pages (from-to)861-871
Number of pages11
JournalAnti-Cancer Agents in Medicinal Chemistry
Volume13
Issue number6
DOIs
Publication statusPublished - 2013

Keywords

  • Adjuvant chemotherapy
  • Endometrial cancer
  • Hormonal therapy
  • Prognostic factors
  • Radiation therapy

ASJC Scopus subject areas

  • Cancer Research
  • Molecular Medicine
  • Pharmacology

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