Multidrug- and extensively drug-resistant tuberculosis, Germany

Barbara Eker, Johannes Ortmann, Giovanni B. Migliori, Giovanni Sotgiu, Ralf Muetterlein, Rosella Centis, Harald Hoffmann, Detlef Kirsten, Tom Schaberg, Sabine Ruesch-Gerdes, Christoph Lange

Research output: Contribution to journalArticle

Abstract

We evaluated risk factors and treatment outcomes associated with multidrug-resistant (MDR) and extensively drug-resistant (XDR) tuberculosis (TB) in Germany in 2004-2006. In 177 (4%) of 4,557 culture-positive TB cases, Mycobacterium tuberculosis isolates were identified as MDR TB; an additional 7 (0.15%) met criteria for XDR TB. Of these 184 patients, 148 (80%) were born in countries of the former Soviet Union. In patients with XDR TB, hospitalization was longer (mean ± SD 202 ± 130 vs. 123 ± 81 days; p = 0.015) and resistance to all first-line drugs was more frequent (36% vs. 86%; p = 0.013) than in patients with MDR TB. Seventyfour (40%) of these 184 patients received treatment with linezolid. Treatment success rates ranged from 59% for the entire cohort (59% for MDR TB and 57% for XDR TB) to 87% for those with a definitive outcome (n = 125; 89% for MDR TB and 80% for XDR TB). Extensive drug susceptibility testing and availability of second- and third-line drugs under inpatient management conditions permit relatively high treatment success rates in MDR and XDR TB.

Original languageEnglish
Pages (from-to)1700-1706
Number of pages7
JournalEmerging Infectious Diseases
Volume14
Issue number11
DOIs
Publication statusPublished - Nov 2008

ASJC Scopus subject areas

  • Microbiology (medical)
  • Infectious Diseases
  • Epidemiology

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  • Cite this

    Eker, B., Ortmann, J., Migliori, G. B., Sotgiu, G., Muetterlein, R., Centis, R., Hoffmann, H., Kirsten, D., Schaberg, T., Ruesch-Gerdes, S., & Lange, C. (2008). Multidrug- and extensively drug-resistant tuberculosis, Germany. Emerging Infectious Diseases, 14(11), 1700-1706. https://doi.org/10.3201/eid1411.080729