Multidrug resistance and cancer stem cells in neuroblastoma and hepatoblastoma

Anna Alisi, William C. Cho, Franco Locatelli, Doriana Fruci

Research output: Contribution to journalArticlepeer-review


Chemotherapy is one of the major modalities in treating cancers. However, its effectiveness is limited by the acquisition of multidrug resistance (MDR). Several mechanisms could explain the up-regulation of MDR genes/proteins in cancer after chemotherapy. It is known that cancer stem cells (CSCs) play a role as master regulators. Therefore, understanding the mechanisms that regulate some traits of CSCs may help design efficient strategies to overcome chemoresistance. Different CSC phenotypes have been identified, including those found in some pediatric malignancies. As solid tumors in children significantly differ from those observed in adults, this review aims at providing an overview of the mechanistic relationship between MDR and CSCs in common solid tumors, and, in particular, focuses on clinical as well as experimental evidence of the relations between CSCs and MDR in neuroblastoma and hepatoblastoma. Finally, some novel approaches, such as concomitant targeting of multiple key transcription factors governing the stemness of CSCs, as well as nanoparticle-based approaches will also be briefly addressed.

Original languageEnglish
Pages (from-to)24706-24725
Number of pages20
JournalInternational Journal of Molecular Sciences
Issue number12
Publication statusPublished - Dec 18 2013


  • Cancer stem cells
  • Hepatoblastoma
  • Multidrug resistance
  • Neuroblastoma

ASJC Scopus subject areas

  • Computer Science Applications
  • Molecular Biology
  • Catalysis
  • Inorganic Chemistry
  • Spectroscopy
  • Organic Chemistry
  • Physical and Theoretical Chemistry


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