Multidrug-resistant pathogens in hospitalised patients coming from the community with pneumonia: A European perspective

Stefano Aliberti, Catia Cilloniz, James D. Chalmers, Anna Maria Zanaboni, Roberto Cosentini, Paolo Tarsia, Alberto Pesci, Francesco Blasi, Antoni Torres

Research output: Contribution to journalArticlepeer-review

Abstract

Background Probabilistic scores have been recently suggested to identify pneumonia caused by multidrugresistant (MDR) bacteria. The aim of the study was to validate both Aliberti and Shorr scores in predicting MDR pneumonia, comparing them with healthcare associated pneumonia (HCAP) classification. Methods Two independent European cohorts of consecutive patients hospitalised with pneumonia were prospectively evaluated in Barcelona, Spain (BC) and Edinburgh, UK (EC). Data on admission and during hospitalisation were collected. The predictive value of the three scores was explored for correctly indicating the presence of MDR pneumonia via a receiver-operating characteristic (ROC) curve. Results A total of 1591 patients in the BC and 1883 patients in the EC were enrolled. The prevalence of patients with MDR pathogen among those with isolated bacteria was 7.6% in the BC and 3.3% in the EC. The most common MDR pathogen found in both cohorts was MRSA, followed by MDR P aeruginosa. A significantly higher prevalence of MDR bacteria was found among patients in the intensive care unit (ICU). The two probabilistic scores, and particularly the Aliberti one, showed an area under the ROC curve higher than the HCAP classification in predicting MDR pneumonia, especially in the ICU. Conclusions Risk scores able to identify MDR pneumonia could help in developing strategies for antimicrobial stewardship.

Original languageEnglish
Pages (from-to)997-999
Number of pages3
JournalThorax
Volume68
Issue number11
DOIs
Publication statusPublished - Nov 2013

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine

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