Multidrug-resistant tuberculosis in the Florence province from 1992 to 1995

Sandra Nutini, E. Tortoli, A. Corrado

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

SETTING: Epidemiological data on the frequency of drug-resistant tuberculosis is not available in Italy. OBJECTIVES: Evaluation of the rate of multidrug-resistant tuberculosis in the Province of Florence, Italy. DESIGN: Retrospective analysis of all sensitivity tests performed with the Bactec method on initial mycobacterial isolates, from 1 January 1992 to 31 December 1995, in the Province of Florence. RESULTS: The following rates of resistance were found in the 433 samples tested: isoniazid + rifampicin 2.5%, at least one drug 13.8% isoniazid 10.6%, rifampicin 3.6%, streptomycin 3.6%, pyrazinamide 1.7% and ethambutol 0.6%. Resistance was higher in foreign-born individuals from high prevalence countries than in the Italian-born population, whereas resistance to streptomycin was more frequent in the latter. The yearly rates of resistance showed no significant variation in the period examined. Clinical data were available in 231 patients: the rate of resistance to at least one drug and to isoniazid + rifampicin were 10.8% and 0%, respectively, in never treated patients, and 28.5% and 7.1%, respectively, in previously treated patients. CONCLUSION: These data show higher multidrug resistance rates than those found in other European countries such as England and Wales, France and Switzerland. This result suggests the need to establish official godliness for the correct treatment of tuberculosis in Italy, in order to prevent the onset of drug resistance, and to establish a national surveillance system for mycobacterial resistance.

Original languageEnglish
Pages (from-to)484-489
Number of pages6
JournalInternational Journal of Tuberculosis and Lung Disease
Volume2
Issue number6
Publication statusPublished - 1998

Fingerprint

Multidrug-Resistant Tuberculosis
Isoniazid
Rifampin
Italy
Streptomycin
Pyrazinamide
Ethambutol
Wales
Multiple Drug Resistance
Switzerland
Drug Resistance
England
Pharmaceutical Preparations
France
Tuberculosis
Population
Therapeutics

Keywords

  • Multidrug-resistant tuberculosis
  • Surveillance

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine

Cite this

Multidrug-resistant tuberculosis in the Florence province from 1992 to 1995. / Nutini, Sandra; Tortoli, E.; Corrado, A.

In: International Journal of Tuberculosis and Lung Disease, Vol. 2, No. 6, 1998, p. 484-489.

Research output: Contribution to journalArticle

Nutini, Sandra ; Tortoli, E. ; Corrado, A. / Multidrug-resistant tuberculosis in the Florence province from 1992 to 1995. In: International Journal of Tuberculosis and Lung Disease. 1998 ; Vol. 2, No. 6. pp. 484-489.
@article{5bb036ea43524827892ecd7e80f9adf3,
title = "Multidrug-resistant tuberculosis in the Florence province from 1992 to 1995",
abstract = "SETTING: Epidemiological data on the frequency of drug-resistant tuberculosis is not available in Italy. OBJECTIVES: Evaluation of the rate of multidrug-resistant tuberculosis in the Province of Florence, Italy. DESIGN: Retrospective analysis of all sensitivity tests performed with the Bactec method on initial mycobacterial isolates, from 1 January 1992 to 31 December 1995, in the Province of Florence. RESULTS: The following rates of resistance were found in the 433 samples tested: isoniazid + rifampicin 2.5{\%}, at least one drug 13.8{\%} isoniazid 10.6{\%}, rifampicin 3.6{\%}, streptomycin 3.6{\%}, pyrazinamide 1.7{\%} and ethambutol 0.6{\%}. Resistance was higher in foreign-born individuals from high prevalence countries than in the Italian-born population, whereas resistance to streptomycin was more frequent in the latter. The yearly rates of resistance showed no significant variation in the period examined. Clinical data were available in 231 patients: the rate of resistance to at least one drug and to isoniazid + rifampicin were 10.8{\%} and 0{\%}, respectively, in never treated patients, and 28.5{\%} and 7.1{\%}, respectively, in previously treated patients. CONCLUSION: These data show higher multidrug resistance rates than those found in other European countries such as England and Wales, France and Switzerland. This result suggests the need to establish official godliness for the correct treatment of tuberculosis in Italy, in order to prevent the onset of drug resistance, and to establish a national surveillance system for mycobacterial resistance.",
keywords = "Multidrug-resistant tuberculosis, Surveillance",
author = "Sandra Nutini and E. Tortoli and A. Corrado",
year = "1998",
language = "English",
volume = "2",
pages = "484--489",
journal = "International Journal of Tuberculosis and Lung Disease",
issn = "1027-3719",
publisher = "International Union against Tubercul. and Lung Dis.",
number = "6",

}

TY - JOUR

T1 - Multidrug-resistant tuberculosis in the Florence province from 1992 to 1995

AU - Nutini, Sandra

AU - Tortoli, E.

AU - Corrado, A.

PY - 1998

Y1 - 1998

N2 - SETTING: Epidemiological data on the frequency of drug-resistant tuberculosis is not available in Italy. OBJECTIVES: Evaluation of the rate of multidrug-resistant tuberculosis in the Province of Florence, Italy. DESIGN: Retrospective analysis of all sensitivity tests performed with the Bactec method on initial mycobacterial isolates, from 1 January 1992 to 31 December 1995, in the Province of Florence. RESULTS: The following rates of resistance were found in the 433 samples tested: isoniazid + rifampicin 2.5%, at least one drug 13.8% isoniazid 10.6%, rifampicin 3.6%, streptomycin 3.6%, pyrazinamide 1.7% and ethambutol 0.6%. Resistance was higher in foreign-born individuals from high prevalence countries than in the Italian-born population, whereas resistance to streptomycin was more frequent in the latter. The yearly rates of resistance showed no significant variation in the period examined. Clinical data were available in 231 patients: the rate of resistance to at least one drug and to isoniazid + rifampicin were 10.8% and 0%, respectively, in never treated patients, and 28.5% and 7.1%, respectively, in previously treated patients. CONCLUSION: These data show higher multidrug resistance rates than those found in other European countries such as England and Wales, France and Switzerland. This result suggests the need to establish official godliness for the correct treatment of tuberculosis in Italy, in order to prevent the onset of drug resistance, and to establish a national surveillance system for mycobacterial resistance.

AB - SETTING: Epidemiological data on the frequency of drug-resistant tuberculosis is not available in Italy. OBJECTIVES: Evaluation of the rate of multidrug-resistant tuberculosis in the Province of Florence, Italy. DESIGN: Retrospective analysis of all sensitivity tests performed with the Bactec method on initial mycobacterial isolates, from 1 January 1992 to 31 December 1995, in the Province of Florence. RESULTS: The following rates of resistance were found in the 433 samples tested: isoniazid + rifampicin 2.5%, at least one drug 13.8% isoniazid 10.6%, rifampicin 3.6%, streptomycin 3.6%, pyrazinamide 1.7% and ethambutol 0.6%. Resistance was higher in foreign-born individuals from high prevalence countries than in the Italian-born population, whereas resistance to streptomycin was more frequent in the latter. The yearly rates of resistance showed no significant variation in the period examined. Clinical data were available in 231 patients: the rate of resistance to at least one drug and to isoniazid + rifampicin were 10.8% and 0%, respectively, in never treated patients, and 28.5% and 7.1%, respectively, in previously treated patients. CONCLUSION: These data show higher multidrug resistance rates than those found in other European countries such as England and Wales, France and Switzerland. This result suggests the need to establish official godliness for the correct treatment of tuberculosis in Italy, in order to prevent the onset of drug resistance, and to establish a national surveillance system for mycobacterial resistance.

KW - Multidrug-resistant tuberculosis

KW - Surveillance

UR - http://www.scopus.com/inward/record.url?scp=0031815991&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0031815991&partnerID=8YFLogxK

M3 - Article

C2 - 9626606

AN - SCOPUS:0031815991

VL - 2

SP - 484

EP - 489

JO - International Journal of Tuberculosis and Lung Disease

JF - International Journal of Tuberculosis and Lung Disease

SN - 1027-3719

IS - 6

ER -