Multidrug‐resistant gram‐negative bacteria decolonization in immunocompromised patients: A focus on fecal microbiota transplantation

Laura Alagna, Emanuele Palomba, Davide Mangioni, Giorgio Bozzi, Andrea Lombardi, Riccardo Ungaro, Valeria Castelli, Daniele Prati, Maurizio Vecchi, Antonio Muscatello, Alessandra Bandera, Andrea Gori

Research output: Contribution to journalReview articlepeer-review


Antimicrobial resistance is an important issue for global health; in immunocompromised patients, such as solid organ and hematological transplant recipients, it poses an even bigger threat. Colonization by multidrug‐resistant (MDR) bacteria was acknowledged as a strong risk factor to subsequent infections, especially in individuals with a compromised immune system. A growing pile of studies has linked the imbalance caused by the dominance of certain taxa populating the gut, also known as intestinal microbiota dysbiosis, to an increased risk of MDR bacteria colonization. Several attempts were proposed to modulate the gut microbiota. Particularly, fecal microbiota transplantation (FMT) was successfully applied to treat conditions like Clostridioides difficile infection and other diseases linked to gut microbiota dysbiosis. In this review we aimed to provide a look at the data gathered so far on FMT, focusing on its possible role in treating MDR colonization in the setting of immunocompromised patients and analyzing its efficacy and safety.

Original languageEnglish
Article number5619
JournalInternational Journal of Molecular Sciences
Issue number16
Publication statusPublished - 2020


  • Antimicrobial resistance
  • Decolonization
  • Dysbiosis
  • Fecal microbiota transplantation
  • Gut colonization
  • Gut microbiota
  • Immunocompromised
  • Multidrug‐resistant

ASJC Scopus subject areas

  • Catalysis
  • Molecular Biology
  • Spectroscopy
  • Computer Science Applications
  • Physical and Theoretical Chemistry
  • Organic Chemistry
  • Inorganic Chemistry


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