Multiexponential T2-relaxation analysis in cerebrally damaged rats in the absence and presence of a gadolinium contrast agent

Alessandro Lascialfari, I. Zucca, M. Asdente, M. Cimino, U. Guerrini, R. Paoletti, E. Tremoli, V. Lorusso, L. Sironi

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An analysis of the multiexponential relaxation of transverse nuclear magnetization with and without a gadolinium-based paramagnetic contrast agent in spontaneously hypertensive stroke-prone rats (SHR-SP) and in the rat model of ischemia induced by middle cerebral artery occlusion is described. From the multiexponential relaxation, the presence of two T2 relaxation times in the range of 0.03-0.5 s, T2A (shortest) and T2B (longest), with very different relative weights (respectively, A and B), is evidenced. In our models of cerebral damage, the changes in A and B were more evident than those in T2A and T2B. The two T2 values were interpreted as belonging to water molecules in two different compartments; therefore, the difference between the damaged and normal regions revealed by means of standard T2-weighted images is suggested to be due to a different water distribution in the two compartments, rather than different T2'S. The T2 relaxation in the SHR-SP stroke model is analyzed for the first time using a multiexponential method. The power of a detailed analysis of MRI relaxation times is confirmed by the correspondence between the revealed changes in T2A, T2B, A and B, and the known T2W and DWI results about blood-brain barrier functionality.

Original languageEnglish
Pages (from-to)1326-1332
Number of pages7
JournalMagnetic Resonance in Medicine
Issue number6
Publication statusPublished - Jun 2005


  • Animal models
  • Cerebral damage
  • Contrast agents
  • Multiexponential relaxation
  • T

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Radiological and Ultrasound Technology


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