Multifaceted aspects of inflammation in multiple sclerosis

The role of microglia

Research output: Contribution to journalArticle

64 Citations (Scopus)

Abstract

The very simplistic view that inflammation in multiple sclerosis (MS) is tout court detrimental has to be profoundly reconsidered. Experimental evidence strongly supports the concept that inflammation in MS is aimed not only at destroying and phagocytosing damaged (infected?) cells (detrimental phase) but also at promoting tissue regeneration or tissue repair via scar formation (resolution or protective phase). Microglia seem to play a crucial role in the different inflammatory phases in MS because they move through multiple functional levels (quantum jumps) either to remove the "danger" signal or to restore the integrity of the central nervous system. The understanding of the molecular signature of any of the quantum microglial states could be useful to better define the cellular and molecular mechanisms underling the different phases of inflammation in MS. This could contribute not only to the design of better therapeutic drugs, but also to the comprehension of the shortcomings of currently used anti-inflammatory drugs.

Original languageEnglish
Pages (from-to)39-44
Number of pages6
JournalJournal of Neuroimmunology
Volume191
Issue number1-2
DOIs
Publication statusPublished - Nov 2007

Fingerprint

Microglia
Multiple Sclerosis
Inflammation
Phagocytosis
Pharmaceutical Preparations
Cicatrix
Regeneration
Anti-Inflammatory Agents
Central Nervous System
Therapeutics

Keywords

  • Inflammation
  • Microglia
  • Multiple sclerosis
  • Quantum states
  • Regeneration

ASJC Scopus subject areas

  • Immunology
  • Immunology and Allergy
  • Clinical Neurology
  • Neurology

Cite this

@article{fd1680e34ca14e9b9df3fe74c743153b,
title = "Multifaceted aspects of inflammation in multiple sclerosis: The role of microglia",
abstract = "The very simplistic view that inflammation in multiple sclerosis (MS) is tout court detrimental has to be profoundly reconsidered. Experimental evidence strongly supports the concept that inflammation in MS is aimed not only at destroying and phagocytosing damaged (infected?) cells (detrimental phase) but also at promoting tissue regeneration or tissue repair via scar formation (resolution or protective phase). Microglia seem to play a crucial role in the different inflammatory phases in MS because they move through multiple functional levels (quantum jumps) either to remove the {"}danger{"} signal or to restore the integrity of the central nervous system. The understanding of the molecular signature of any of the quantum microglial states could be useful to better define the cellular and molecular mechanisms underling the different phases of inflammation in MS. This could contribute not only to the design of better therapeutic drugs, but also to the comprehension of the shortcomings of currently used anti-inflammatory drugs.",
keywords = "Inflammation, Microglia, Multiple sclerosis, Quantum states, Regeneration",
author = "Luca Muzio and Gianvito Martino and Roberto Furlan",
year = "2007",
month = "11",
doi = "10.1016/j.jneuroim.2007.09.016",
language = "English",
volume = "191",
pages = "39--44",
journal = "Journal of Neuroimmunology",
issn = "0165-5728",
publisher = "Elsevier Science B.V.",
number = "1-2",

}

TY - JOUR

T1 - Multifaceted aspects of inflammation in multiple sclerosis

T2 - The role of microglia

AU - Muzio, Luca

AU - Martino, Gianvito

AU - Furlan, Roberto

PY - 2007/11

Y1 - 2007/11

N2 - The very simplistic view that inflammation in multiple sclerosis (MS) is tout court detrimental has to be profoundly reconsidered. Experimental evidence strongly supports the concept that inflammation in MS is aimed not only at destroying and phagocytosing damaged (infected?) cells (detrimental phase) but also at promoting tissue regeneration or tissue repair via scar formation (resolution or protective phase). Microglia seem to play a crucial role in the different inflammatory phases in MS because they move through multiple functional levels (quantum jumps) either to remove the "danger" signal or to restore the integrity of the central nervous system. The understanding of the molecular signature of any of the quantum microglial states could be useful to better define the cellular and molecular mechanisms underling the different phases of inflammation in MS. This could contribute not only to the design of better therapeutic drugs, but also to the comprehension of the shortcomings of currently used anti-inflammatory drugs.

AB - The very simplistic view that inflammation in multiple sclerosis (MS) is tout court detrimental has to be profoundly reconsidered. Experimental evidence strongly supports the concept that inflammation in MS is aimed not only at destroying and phagocytosing damaged (infected?) cells (detrimental phase) but also at promoting tissue regeneration or tissue repair via scar formation (resolution or protective phase). Microglia seem to play a crucial role in the different inflammatory phases in MS because they move through multiple functional levels (quantum jumps) either to remove the "danger" signal or to restore the integrity of the central nervous system. The understanding of the molecular signature of any of the quantum microglial states could be useful to better define the cellular and molecular mechanisms underling the different phases of inflammation in MS. This could contribute not only to the design of better therapeutic drugs, but also to the comprehension of the shortcomings of currently used anti-inflammatory drugs.

KW - Inflammation

KW - Microglia

KW - Multiple sclerosis

KW - Quantum states

KW - Regeneration

UR - http://www.scopus.com/inward/record.url?scp=35848957483&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=35848957483&partnerID=8YFLogxK

U2 - 10.1016/j.jneuroim.2007.09.016

DO - 10.1016/j.jneuroim.2007.09.016

M3 - Article

VL - 191

SP - 39

EP - 44

JO - Journal of Neuroimmunology

JF - Journal of Neuroimmunology

SN - 0165-5728

IS - 1-2

ER -