Multifaceted functions of B cells in chronic hepatitis C virus infection

Research output: Contribution to journalArticle

Abstract

Hepatitis C virus (HCV) elicits T- and B-cell responses which are believed to play an important role in infection control. B cells have generally been neglected because they do not seem to significantly influence the course of HCV infection. In this review, B lymphocytes are viewed both as classical antibody producing cells, with the hypervariable region 1 being a biologically relevant target protein and as a model of virus-host interaction in lymphoproliferative disorders characteristic of persistent microbial infections.

Original languageEnglish
Pages (from-to)111-115
Number of pages5
JournalAntiviral Research
Volume60
Issue number2
DOIs
Publication statusPublished - Oct 2003

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Chronic Hepatitis C
Virus Diseases
Hepacivirus
B-Lymphocytes
Antibody-Producing Cells
Lymphoproliferative Disorders
Infection Control
Viruses
Infection
Proteins

Keywords

  • B lymphocytes
  • HCV
  • HVR1

ASJC Scopus subject areas

  • Virology
  • Pharmacology

Cite this

Multifaceted functions of B cells in chronic hepatitis C virus infection. / Mondelli, Mario U.

In: Antiviral Research, Vol. 60, No. 2, 10.2003, p. 111-115.

Research output: Contribution to journalArticle

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