Abstract
Tumor progression is subject to modulation by the immune system. The immune system can eliminate tumors or keep them at a dormant equilibrium size, while some tumors escape immunomodulation and advance to malignancy. Herein, we discuss some aspects of immune evasion of dormant tumors from a theoretical biophysics point of view that can be modeled mathematically. We go on to analyze the mathematical system on multiple timescales. First, we consider a long timescale where tumor evasion is likely due to adaptive (and somewhat deterministic) immuno-editing. Then, we consider the temporal mesoscale and hypothesize that extrinsic noise could be a major factor in induction of immuno-evasion. Implications of immuno-evasive mechanisms for the outcome of immunotherapies are also discussed. In addition, we discuss the ideas that population level tumor dormancy may not be a quiescence phenomenon and that dormant tumors can, at least if modulated by the immune system, live a very active and noisy life!
| Original language | English |
|---|---|
| Title of host publication | Advances in Experimental Medicine and Biology |
| Pages | 111-143 |
| Number of pages | 33 |
| Volume | 734 |
| DOIs | |
| Publication status | Published - 2013 |
Publication series
| Name | Advances in Experimental Medicine and Biology |
|---|---|
| Volume | 734 |
| ISSN (Print) | 00652598 |
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Keywords
- Immune system
- Immuno-evasion
- Immunoediting
- Systems biomedicine
- Tumor dormancy
ASJC Scopus subject areas
- Biochemistry, Genetics and Molecular Biology(all)
- Medicine(all)
Cite this
Multifaceted kinetics of immuno-evasion from tumor dormancy. / D'Onofrio, Alberto.
Advances in Experimental Medicine and Biology. Vol. 734 2013. p. 111-143 (Advances in Experimental Medicine and Biology; Vol. 734).Research output: Chapter in Book/Report/Conference proceeding › Chapter
}
TY - CHAP
T1 - Multifaceted kinetics of immuno-evasion from tumor dormancy
AU - D'Onofrio, Alberto
PY - 2013
Y1 - 2013
N2 - Tumor progression is subject to modulation by the immune system. The immune system can eliminate tumors or keep them at a dormant equilibrium size, while some tumors escape immunomodulation and advance to malignancy. Herein, we discuss some aspects of immune evasion of dormant tumors from a theoretical biophysics point of view that can be modeled mathematically. We go on to analyze the mathematical system on multiple timescales. First, we consider a long timescale where tumor evasion is likely due to adaptive (and somewhat deterministic) immuno-editing. Then, we consider the temporal mesoscale and hypothesize that extrinsic noise could be a major factor in induction of immuno-evasion. Implications of immuno-evasive mechanisms for the outcome of immunotherapies are also discussed. In addition, we discuss the ideas that population level tumor dormancy may not be a quiescence phenomenon and that dormant tumors can, at least if modulated by the immune system, live a very active and noisy life!
AB - Tumor progression is subject to modulation by the immune system. The immune system can eliminate tumors or keep them at a dormant equilibrium size, while some tumors escape immunomodulation and advance to malignancy. Herein, we discuss some aspects of immune evasion of dormant tumors from a theoretical biophysics point of view that can be modeled mathematically. We go on to analyze the mathematical system on multiple timescales. First, we consider a long timescale where tumor evasion is likely due to adaptive (and somewhat deterministic) immuno-editing. Then, we consider the temporal mesoscale and hypothesize that extrinsic noise could be a major factor in induction of immuno-evasion. Implications of immuno-evasive mechanisms for the outcome of immunotherapies are also discussed. In addition, we discuss the ideas that population level tumor dormancy may not be a quiescence phenomenon and that dormant tumors can, at least if modulated by the immune system, live a very active and noisy life!
KW - Immune system
KW - Immuno-evasion
KW - Immunoediting
KW - Systems biomedicine
KW - Tumor dormancy
UR - http://www.scopus.com/inward/record.url?scp=84875811951&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84875811951&partnerID=8YFLogxK
U2 - 10.1007/978-1-4614-1445-2_7
DO - 10.1007/978-1-4614-1445-2_7
M3 - Chapter
C2 - 23143978
AN - SCOPUS:84875811951
SN - 9781461441175
VL - 734
T3 - Advances in Experimental Medicine and Biology
SP - 111
EP - 143
BT - Advances in Experimental Medicine and Biology
ER -