Multifactorial control of insulin receptor gene expression in human cell lines

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Taking advantage of a computer program to align DNA sequences we scanned the 5′-flanking region of the insulin receptor gene to localize putative regulatory elements. Using this approach as a start point, we investigated the effect of several agents on insulin receptor gene expression in human cells. We found that (i) forskolin reduces insulin receptor mRNA levels; (ii) the effects of either forskolin or dexamethasone on insulin receptor mRNA levels are near completely abolished in glucose-starved cells; (iii) 2-mercaptoethanol and heat shock, besides previously described stress conditions (glycosylatyon inhibitors), reduce insulin receptor mRNA levels.

Original languageEnglish
Pages (from-to)1184-1190
Number of pages7
JournalBiochemical and Biophysical Research Communications
Issue number3
Publication statusPublished - Aug 16 1990

ASJC Scopus subject areas

  • Biochemistry
  • Biophysics
  • Molecular Biology


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