Multifocal osteosarcoma as second tumor after childhood retinoblastoma

Paolo Potepan, Roberto Luksch, Gabriella Sozzi, Adele Testi, Alberto Laffranchi, Gian Maria Danesini, Antonina Parafioriti, Roberto Giardini, Ivo Spagnoli

Research output: Contribution to journalArticlepeer-review


We present a case of multifocal osteosarcoma (MFOS) arising 11.5 years after successful treatment of bilateral retinoblastoma. The clinical, imaging and pathological findings at onset, after therapy and during follow-up are described. Fluorescent in situ hybridization did not reveal a deletion of the RB-1 retinoblastoma gene, although the presence of an inactivating mutation invisible to this method cannot be ruled out. The MFOS may have been a second multifocal tumor associated with the original retinoblastoma or a post-irradiation sarcoma with extensive metastases.

Original languageEnglish
Pages (from-to)415-421
Number of pages7
JournalSkeletal Radiology
Issue number7
Publication statusPublished - Jul 1999


  • Osteosarcoma, multifocal
  • Radiography
  • Retinoblastoma

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Radiological and Ultrasound Technology


Dive into the research topics of 'Multifocal osteosarcoma as second tumor after childhood retinoblastoma'. Together they form a unique fingerprint.

Cite this