Multifocal presentation of medulloblastoma in adulthood

Pietro Ciccarino, Antonino Rotilio, Marta Rossetto, Renzo Manara, Enrico Orvieto, Franco Berti, Giuseppe Lombardi, Domenico D'Avella, Renato Scienza, Alessandro Della Puppa

Research output: Contribution to journalArticle

Abstract

Medulloblastoma in adulthood is uncommon but not rare; annual incidence is 2-20/1,000,000. Some peculiarities characterize medulloblastoma in adult patients compared with the child type: lateral cerebellar location, heterogeneous signal intensity on magnetic resonance imaging, desmoplastic histological variant, and more favourable prognosis. Preoperative diagnosis is crucial for correct management of these patients. However, because of the low incidence of medulloblastoma in the adult population, preoperative diagnosis remains challenging and prognostic factors and best treatment options are still controversial. In this setting, some unusual findings, for example multifocal presentation and extra-axial location, can confound diagnosis and make treatment difficult. We present a short case-illustrated review on these remarkable issues.

Original languageEnglish
Pages (from-to)233-237
Number of pages5
JournalJournal of Neuro-Oncology
Volume107
Issue number2
DOIs
Publication statusPublished - Apr 2012

Keywords

  • Adulthood
  • Medulloblastoma
  • Multifocal presentation

ASJC Scopus subject areas

  • Clinical Neurology
  • Cancer Research
  • Oncology
  • Neurology

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  • Cite this

    Ciccarino, P., Rotilio, A., Rossetto, M., Manara, R., Orvieto, E., Berti, F., Lombardi, G., D'Avella, D., Scienza, R., & Della Puppa, A. (2012). Multifocal presentation of medulloblastoma in adulthood. Journal of Neuro-Oncology, 107(2), 233-237. https://doi.org/10.1007/s11060-011-0746-7