Abstract
Purpose: To differentiate the bioelectrical cortical responses driven by axons from central and mid-peripheral retina in Leber’s hereditary optic neuropathy (LHON) by using multifocal visual evoked potentials (mfVEP). Methods: Seventeen genetically confirmed LHON patients (33.35 ± 8.4 years, 17 eyes) and 22 age-matched controls (C) (38.2 ± 6.0 years, 22 eyes) were studied by mfVEP and optical coherence tomography. MfVEP P1 implicit time (P1 IT, ms) and response amplitude density of the N1-P1 components (N1-P1 RAD, nV/deg2) of the second order binary kernel were measured for five concentric retinal areas between the fovea and mid-periphery: 0–20 degrees (R1 to R5). Results: Mean mfVEP P1 ITs and N1-P1 RADs at all five foveal eccentricities were significantly different (p <0.01) in LHON when compared to controls. In both groups, mean mfVEP responses obtained from R1 to R5 showed a progressive shortening of P1 ITs (linear fitting, LHON: r = −0.95; C: r = −0.98) and decrease of N1-P1 RADs (exponential fitting, LHON: r2 = 0.94; C: r2 = 0.93). The slope of the linear fitting between mean mfVEP P1 ITs in the two groups was about three times greater in LHON than in controls (LHON: y = −13.33x +182.03; C: y = −4.528x +108.1). MfVEP P1 ITs detected in R1 and R2 (0–5 degrees) were significantly correlated (p <0.01) with the reduction of retinal nerve fiber layer thickness of the temporal quadrant. Conclusions: MfVEP identifies abnormal neural conduction along the visual pathways in LHON, discriminating a predominant involvement of axons driving responses from the central retina when compared to those serving the mid-peripheral retina.
| Original language | English |
|---|---|
| Pages (from-to) | 1591-1600 |
| Number of pages | 10 |
| Journal | Graefe's Archive for Clinical and Experimental Ophthalmology |
| Volume | 253 |
| Issue number | 9 |
| DOIs | |
| Publication status | Published - Sep 26 2015 |
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Keywords
- Leber’s hereditary optic neuropathy
- LHON
- Mitochondrial optic neuropathy
- Multifocal visual evoked potentials
- Retinal ganglion cells function
ASJC Scopus subject areas
- Ophthalmology
- Sensory Systems
- Cellular and Molecular Neuroscience
- Medicine(all)
Cite this
Multifocal VEP provide electrophysiological evidence of predominant dysfunction of the optic nerve fibers derived from the central retina in Leber’s hereditary optic neuropathy. / Ziccardi, Lucia; Parisi, Vincenzo; Giannini, Daniela; Sadun, Federico; De Negri, Anna Maria; Barboni, Piero; La Morgia, Chiara; Sadun, Alfedo A.; Carelli, Valerio.
In: Graefe's Archive for Clinical and Experimental Ophthalmology, Vol. 253, No. 9, 26.09.2015, p. 1591-1600.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Multifocal VEP provide electrophysiological evidence of predominant dysfunction of the optic nerve fibers derived from the central retina in Leber’s hereditary optic neuropathy
AU - Ziccardi, Lucia
AU - Parisi, Vincenzo
AU - Giannini, Daniela
AU - Sadun, Federico
AU - De Negri, Anna Maria
AU - Barboni, Piero
AU - La Morgia, Chiara
AU - Sadun, Alfedo A.
AU - Carelli, Valerio
PY - 2015/9/26
Y1 - 2015/9/26
N2 - Purpose: To differentiate the bioelectrical cortical responses driven by axons from central and mid-peripheral retina in Leber’s hereditary optic neuropathy (LHON) by using multifocal visual evoked potentials (mfVEP). Methods: Seventeen genetically confirmed LHON patients (33.35 ± 8.4 years, 17 eyes) and 22 age-matched controls (C) (38.2 ± 6.0 years, 22 eyes) were studied by mfVEP and optical coherence tomography. MfVEP P1 implicit time (P1 IT, ms) and response amplitude density of the N1-P1 components (N1-P1 RAD, nV/deg2) of the second order binary kernel were measured for five concentric retinal areas between the fovea and mid-periphery: 0–20 degrees (R1 to R5). Results: Mean mfVEP P1 ITs and N1-P1 RADs at all five foveal eccentricities were significantly different (p <0.01) in LHON when compared to controls. In both groups, mean mfVEP responses obtained from R1 to R5 showed a progressive shortening of P1 ITs (linear fitting, LHON: r = −0.95; C: r = −0.98) and decrease of N1-P1 RADs (exponential fitting, LHON: r2 = 0.94; C: r2 = 0.93). The slope of the linear fitting between mean mfVEP P1 ITs in the two groups was about three times greater in LHON than in controls (LHON: y = −13.33x +182.03; C: y = −4.528x +108.1). MfVEP P1 ITs detected in R1 and R2 (0–5 degrees) were significantly correlated (p <0.01) with the reduction of retinal nerve fiber layer thickness of the temporal quadrant. Conclusions: MfVEP identifies abnormal neural conduction along the visual pathways in LHON, discriminating a predominant involvement of axons driving responses from the central retina when compared to those serving the mid-peripheral retina.
AB - Purpose: To differentiate the bioelectrical cortical responses driven by axons from central and mid-peripheral retina in Leber’s hereditary optic neuropathy (LHON) by using multifocal visual evoked potentials (mfVEP). Methods: Seventeen genetically confirmed LHON patients (33.35 ± 8.4 years, 17 eyes) and 22 age-matched controls (C) (38.2 ± 6.0 years, 22 eyes) were studied by mfVEP and optical coherence tomography. MfVEP P1 implicit time (P1 IT, ms) and response amplitude density of the N1-P1 components (N1-P1 RAD, nV/deg2) of the second order binary kernel were measured for five concentric retinal areas between the fovea and mid-periphery: 0–20 degrees (R1 to R5). Results: Mean mfVEP P1 ITs and N1-P1 RADs at all five foveal eccentricities were significantly different (p <0.01) in LHON when compared to controls. In both groups, mean mfVEP responses obtained from R1 to R5 showed a progressive shortening of P1 ITs (linear fitting, LHON: r = −0.95; C: r = −0.98) and decrease of N1-P1 RADs (exponential fitting, LHON: r2 = 0.94; C: r2 = 0.93). The slope of the linear fitting between mean mfVEP P1 ITs in the two groups was about three times greater in LHON than in controls (LHON: y = −13.33x +182.03; C: y = −4.528x +108.1). MfVEP P1 ITs detected in R1 and R2 (0–5 degrees) were significantly correlated (p <0.01) with the reduction of retinal nerve fiber layer thickness of the temporal quadrant. Conclusions: MfVEP identifies abnormal neural conduction along the visual pathways in LHON, discriminating a predominant involvement of axons driving responses from the central retina when compared to those serving the mid-peripheral retina.
KW - Leber’s hereditary optic neuropathy
KW - LHON
KW - Mitochondrial optic neuropathy
KW - Multifocal visual evoked potentials
KW - Retinal ganglion cells function
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U2 - 10.1007/s00417-015-2979-1
DO - 10.1007/s00417-015-2979-1
M3 - Article
VL - 253
SP - 1591
EP - 1600
JO - Graefe's Archive for Clinical and Experimental Ophthalmology
JF - Graefe's Archive for Clinical and Experimental Ophthalmology
SN - 0721-832X
IS - 9
ER -