Multilayered Magnetic Gelatin Membrane Scaffolds

Sangram K. Samal, Vitaly Goranov, Mamoni Dash, Alessandro Russo, Tatiana Shelyakova, Patrizio Graziosi, Lisa Lungaro, Alberto Riminucci, Marc Uhlarz, Manuel Bañobre-López, Jose Rivas, Thomas Herrmannsdörfer, Jayakumar Rajadas, Stefaan De Smedt, Kevin Braeckmans, David L. Kaplan, V. Alek Dediu

Research output: Contribution to journalArticle

Abstract

A versatile approach for the design and fabrication of multilayer magnetic scaffolds with tunable magnetic gradients is described. Multilayer magnetic gelatin membrane scaffolds with intrinsic magnetic gradients were designed to encapsulate magnetized bioagents under an externally applied magnetic field for use in magnetic-field-assisted tissue engineering. The temperature of the individual membranes increased up to 43.7 °C under an applied oscillating magnetic field for 70 s by magnetic hyperthermia, enabling the possibility of inducing a thermal gradient inside the final 3D multilayer magnetic scaffolds. On the basis of finite element method simulations, magnetic gelatin membranes with different concentrations of magnetic nanoparticles were assembled into 3D multilayered scaffolds. A magnetic-gradient-controlled distribution of magnetically labeled stem cells was demonstrated in vitro. This magnetic biomaterial-magnetic cell strategy can be expanded to a number of different magnetic biomaterials for various tissue engineering applications.

Original languageEnglish
Pages (from-to)23098-23109
Number of pages12
JournalACS Applied Materials and Interfaces
Volume7
Issue number41
DOIs
Publication statusPublished - Oct 21 2015

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Keywords

  • biomaterials
  • gelatin
  • gradient
  • magnetic
  • nanoparticles
  • scaffold
  • tissue engineering

ASJC Scopus subject areas

  • Materials Science(all)

Cite this

Samal, S. K., Goranov, V., Dash, M., Russo, A., Shelyakova, T., Graziosi, P., Lungaro, L., Riminucci, A., Uhlarz, M., Bañobre-López, M., Rivas, J., Herrmannsdörfer, T., Rajadas, J., De Smedt, S., Braeckmans, K., Kaplan, D. L., & Dediu, V. A. (2015). Multilayered Magnetic Gelatin Membrane Scaffolds. ACS Applied Materials and Interfaces, 7(41), 23098-23109. https://doi.org/10.1021/acsami.5b06813