Multilocus analysis of the fragile X syndrome

W. T. Brown, A. Gross, C. Chan, E. C. Jenkins, J. L. Mandel, I. Oberlé, B. Arveiler, G. Novelli, S. Thibodeau, R. Hagerman, K. Summers, G. Turner, B. N. White, L. Mulligan, C. Forster-Gibson, J. J A Holden, B. Zoll, M. Krawczak, P. Goonewardena, K. H. Gustavson & 8 others U. Pettersson, G. Holmgren, C. Schwartz, P. N. Howard-Peebles, P. Murphy, W. R. Breg, H. Veenema, N. J. Carpenter

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Abstract

A multilocus analysis of the fragile X (fra(X)) syndrome was conducted with 147 families. Two proximal loci, DXS51 and F9, and two distal loci, DXS52 and DXS15, were studied. Overall, the best multipoint distances were found to be DXS51-F9, 6.9%, F9-fra(X), 22.4%; fra(X)-DXS52, 12.7%; DXS52-DXS15, 2.2%. These distances can be used for multipoint mapping of new probes, carrier testing and counseling of fra(X) families. Consistent with several previous studies, the families as a whole showed genetic heterogeneity for linkage between F9 and fra(X).

Original languageEnglish
Pages (from-to)201-205
Number of pages5
JournalHuman Genetics
Volume78
Issue number3
DOIs
Publication statusPublished - Mar 1988

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Fragile X Syndrome
Genetic Linkage
Genetic Heterogeneity
Counseling

ASJC Scopus subject areas

  • Genetics(clinical)
  • Genetics

Cite this

Brown, W. T., Gross, A., Chan, C., Jenkins, E. C., Mandel, J. L., Oberlé, I., ... Carpenter, N. J. (1988). Multilocus analysis of the fragile X syndrome. Human Genetics, 78(3), 201-205. https://doi.org/10.1007/BF00291662

Multilocus analysis of the fragile X syndrome. / Brown, W. T.; Gross, A.; Chan, C.; Jenkins, E. C.; Mandel, J. L.; Oberlé, I.; Arveiler, B.; Novelli, G.; Thibodeau, S.; Hagerman, R.; Summers, K.; Turner, G.; White, B. N.; Mulligan, L.; Forster-Gibson, C.; Holden, J. J A; Zoll, B.; Krawczak, M.; Goonewardena, P.; Gustavson, K. H.; Pettersson, U.; Holmgren, G.; Schwartz, C.; Howard-Peebles, P. N.; Murphy, P.; Breg, W. R.; Veenema, H.; Carpenter, N. J.

In: Human Genetics, Vol. 78, No. 3, 03.1988, p. 201-205.

Research output: Contribution to journalArticle

Brown, WT, Gross, A, Chan, C, Jenkins, EC, Mandel, JL, Oberlé, I, Arveiler, B, Novelli, G, Thibodeau, S, Hagerman, R, Summers, K, Turner, G, White, BN, Mulligan, L, Forster-Gibson, C, Holden, JJA, Zoll, B, Krawczak, M, Goonewardena, P, Gustavson, KH, Pettersson, U, Holmgren, G, Schwartz, C, Howard-Peebles, PN, Murphy, P, Breg, WR, Veenema, H & Carpenter, NJ 1988, 'Multilocus analysis of the fragile X syndrome', Human Genetics, vol. 78, no. 3, pp. 201-205. https://doi.org/10.1007/BF00291662
Brown WT, Gross A, Chan C, Jenkins EC, Mandel JL, Oberlé I et al. Multilocus analysis of the fragile X syndrome. Human Genetics. 1988 Mar;78(3):201-205. https://doi.org/10.1007/BF00291662
Brown, W. T. ; Gross, A. ; Chan, C. ; Jenkins, E. C. ; Mandel, J. L. ; Oberlé, I. ; Arveiler, B. ; Novelli, G. ; Thibodeau, S. ; Hagerman, R. ; Summers, K. ; Turner, G. ; White, B. N. ; Mulligan, L. ; Forster-Gibson, C. ; Holden, J. J A ; Zoll, B. ; Krawczak, M. ; Goonewardena, P. ; Gustavson, K. H. ; Pettersson, U. ; Holmgren, G. ; Schwartz, C. ; Howard-Peebles, P. N. ; Murphy, P. ; Breg, W. R. ; Veenema, H. ; Carpenter, N. J. / Multilocus analysis of the fragile X syndrome. In: Human Genetics. 1988 ; Vol. 78, No. 3. pp. 201-205.
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AU - Oberlé, I.

AU - Arveiler, B.

AU - Novelli, G.

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AU - Turner, G.

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AU - Mulligan, L.

AU - Forster-Gibson, C.

AU - Holden, J. J A

AU - Zoll, B.

AU - Krawczak, M.

AU - Goonewardena, P.

AU - Gustavson, K. H.

AU - Pettersson, U.

AU - Holmgren, G.

AU - Schwartz, C.

AU - Howard-Peebles, P. N.

AU - Murphy, P.

AU - Breg, W. R.

AU - Veenema, H.

AU - Carpenter, N. J.

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