Multilocus genotypic analysis of Cryptosporidium parvum isolates from different hosts and geographical origins

Furio Spano, Lorenza Putignani, Andrea Crisanti, Pina Sallicandro, Una M. Morgan, Sylvie M. Le Blancq, Laurie Tchack, Saul Tzipori, Giovanni Widmer

Research output: Contribution to journalArticle

Abstract

The genetic analysis of oocysts recovered from the stools of humans and animals infected with Cryptosporidium parvum has consistently shown the existence of two distinct genotypes. One of the genotypes is found exclusively in some human infections, whereas the other genotype is found in human as well as in animal infections. On the basis of these observations and the results of published epidemiological studies with single polymorphic markers, the existence of two separate transmission cycles has been postulated, one exclusively anthroponotic and the other involving both animals and humans. To test this hypothesis, C. parvum isolates of different geographic and host origins were analyzed by using unlinked genetic polymorphisms. A total of 28 isolates originating from Europe, North and South America, and Australia were examined. Isolates clustered into two groups, one comprising both human and animal isolates and the other comprising isolates only of human origin. The absence of recombinant genotypes is consistent with two reproductively isolated populations within the species C. parvum.

Original languageEnglish
Pages (from-to)3255-3259
Number of pages5
JournalJournal of Clinical Microbiology
Volume36
Issue number11
Publication statusPublished - Nov 1998

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Cryptosporidium parvum
Genotype
South Australia
Oocysts
South America
Genetic Polymorphisms
North America
Infection
Epidemiologic Studies
Population

ASJC Scopus subject areas

  • Microbiology (medical)
  • Microbiology

Cite this

Spano, F., Putignani, L., Crisanti, A., Sallicandro, P., Morgan, U. M., Le Blancq, S. M., ... Widmer, G. (1998). Multilocus genotypic analysis of Cryptosporidium parvum isolates from different hosts and geographical origins. Journal of Clinical Microbiology, 36(11), 3255-3259.

Multilocus genotypic analysis of Cryptosporidium parvum isolates from different hosts and geographical origins. / Spano, Furio; Putignani, Lorenza; Crisanti, Andrea; Sallicandro, Pina; Morgan, Una M.; Le Blancq, Sylvie M.; Tchack, Laurie; Tzipori, Saul; Widmer, Giovanni.

In: Journal of Clinical Microbiology, Vol. 36, No. 11, 11.1998, p. 3255-3259.

Research output: Contribution to journalArticle

Spano, F, Putignani, L, Crisanti, A, Sallicandro, P, Morgan, UM, Le Blancq, SM, Tchack, L, Tzipori, S & Widmer, G 1998, 'Multilocus genotypic analysis of Cryptosporidium parvum isolates from different hosts and geographical origins', Journal of Clinical Microbiology, vol. 36, no. 11, pp. 3255-3259.
Spano, Furio ; Putignani, Lorenza ; Crisanti, Andrea ; Sallicandro, Pina ; Morgan, Una M. ; Le Blancq, Sylvie M. ; Tchack, Laurie ; Tzipori, Saul ; Widmer, Giovanni. / Multilocus genotypic analysis of Cryptosporidium parvum isolates from different hosts and geographical origins. In: Journal of Clinical Microbiology. 1998 ; Vol. 36, No. 11. pp. 3255-3259.
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