Multimodal evoked potentials in progressive external ophthalmoplegia with mitochondrial myopathy

M. Versino, G. Piccolo, R. Callieco, R. Bergamaschi, P. Banfi, G. Azan, R. Rizzuto, V. Cosi

Research output: Contribution to journalArticlepeer-review

Abstract

Multimodal evoked potentials were studied in 13 patients affected by progressive external ophthalmoplegia with histologically proven mitochondrial myopathy. Progressive external ophthalmoplegia occurred with craniosomatic spreading in all the patients and with a varying degree of nervous and/or other system involvement in most of them. In all but one of the subjects, at least one evoked potential modality was abnormal; 11 of them demonstrated an abnormal visual evoked potential, but this finding might have been influenced by concurrent retinal dysfunction. Abnormalities in brainstem auditory evoked potentials and/or somatosensory evoked potentials,revealing an impairment of central sensory pathways, were detected in 7 subjects, 5 of whom lacked clinical evidence of central nervous system involvement. Thus, evoked potentials represent a useful tool for the detection of subclinical central nervous system involvement in patients affected by progressive external ophthalmoplegia with mitochondrial myopathy.

Original languageEnglish
Pages (from-to)107-110
Number of pages4
JournalActa Neurologica Scandinavica
Volume84
Issue number2
Publication statusPublished - 1991

Keywords

  • CNS involvement
  • mitochondrial myopathy
  • multimodal evoked potentials
  • progressive external ophthalmoplegia

ASJC Scopus subject areas

  • Clinical Neurology
  • Neuroscience(all)

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