Multimodal evoked potentials to assess the evolution of multiple sclerosis: A longitudinal study

L. Leocani, M. Rovaris, F. M. Boneschi, S. Medaglini, P. Rossi, V. Martinelli, S. Amadio, G. Comi

Research output: Contribution to journalArticle

Abstract

Background: Evoked potentials are used in the functional assessment of sensory and motor pathways. Their usefulness in monitoring the evolution of multiple sclerosis has not been fully clarified. Objective: The aim of this longitudinal study was to examine the usefulness of multimodal evoked potential in predicting paraclinical outcomes of disease severity and as a prognostic marker in multiple sclerosis. Methods: Eighty four patients with clinically definite multiple sclerosis underwent Expanded Disability Status Scale (EDSS) and functional system scoring at study entry and after a mean (standard deviation) follow-up of 30.5 (11.7) months. Sensory and motor evoked potentials were obtained in all patients at study entry and at follow-up in 64 of them, and quantified according to a conventional score. Results: Cross-sectionally, the severity of each evoked potential score significantly correlated with the corresponding functional system (0.32

Original languageEnglish
Pages (from-to)1030-1035
Number of pages6
JournalJournal of Neurology, Neurosurgery and Psychiatry
Volume77
Issue number9
DOIs
Publication statusPublished - Sep 2006

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Neuroscience(all)
  • Neuropsychology and Physiological Psychology

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