Multimodal fMRI tractography in normal subjects and in clinically recovered traumatic brain injury patients

Andrea Cherubini, Giacomo Luccichenti, Patrice Péran, Gisela E. Hagberg, Carmen Barba, Rita Formisano, Umberto Sabatini

Research output: Contribution to journalArticle

24 Citations (Scopus)

Abstract

In this study, we defined an operator-independent protocol for reconstructing the anatomical connections originating from fMRI activations in order to demonstrate that results obtained with this protocol are affected by alterations of functional activations. Seven healthy volunteers and two patients who sustained traumatic brain injury underwent an fMRI with a finger tapping task and a DTI scan. Cortical fMRI activations were used directly as seed mask for tractography for the reconstruction of individual motor pathways. On patients we observed a different motor network if compared to healthy subjects. However, when the activations of healthy subjects were used as seed masks for the tractography in patients, we observed for the patients a pattern of connectivity more similar to what was observed for healthy subjects. At the same time, when the activations of patients were used for the tractography on healthy subjects, we obtained patterns of connectivity similar to those obtained for patients. These results show the potential of the integration of fMRI and tractography for clarifying the mechanisms of cortical plasticity in the recovery of motor functions.

Original languageEnglish
Pages (from-to)1331-1341
Number of pages11
JournalNeuroImage
Volume34
Issue number4
DOIs
Publication statusPublished - Feb 15 2007

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Magnetic Resonance Imaging
Healthy Volunteers
Masks
Seeds
Efferent Pathways
Recovery of Function
Fingers
Traumatic Brain Injury

Keywords

  • Connectivity
  • Cortical plasticity
  • Functional MRI
  • Motor pathways
  • Motor-deficit
  • Probabilistic tractography

ASJC Scopus subject areas

  • Cognitive Neuroscience
  • Neurology

Cite this

Multimodal fMRI tractography in normal subjects and in clinically recovered traumatic brain injury patients. / Cherubini, Andrea; Luccichenti, Giacomo; Péran, Patrice; Hagberg, Gisela E.; Barba, Carmen; Formisano, Rita; Sabatini, Umberto.

In: NeuroImage, Vol. 34, No. 4, 15.02.2007, p. 1331-1341.

Research output: Contribution to journalArticle

Cherubini, A, Luccichenti, G, Péran, P, Hagberg, GE, Barba, C, Formisano, R & Sabatini, U 2007, 'Multimodal fMRI tractography in normal subjects and in clinically recovered traumatic brain injury patients', NeuroImage, vol. 34, no. 4, pp. 1331-1341. https://doi.org/10.1016/j.neuroimage.2006.11.024
Cherubini, Andrea ; Luccichenti, Giacomo ; Péran, Patrice ; Hagberg, Gisela E. ; Barba, Carmen ; Formisano, Rita ; Sabatini, Umberto. / Multimodal fMRI tractography in normal subjects and in clinically recovered traumatic brain injury patients. In: NeuroImage. 2007 ; Vol. 34, No. 4. pp. 1331-1341.
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