Multimodal imaging in Alzheimer's disease: Validity and usefulness for early detection

Stefan Teipel, Alexander Drzezga, Michel J. Grothe, Henryk Barthel, Gaël Chételat, Norbert Schuff, Pawel Skudlarski, Enrica Cavedo, Giovanni B. Frisoni, Wolfgang Hoffmann, Jochen René Thyrian, Chris Fox, Satoshi Minoshima, Osama Sabri, Andreas Fellgiebel

Research output: Contribution to journalArticlepeer-review

Abstract

Alzheimer's disease is a progressive neurodegenerative disease that typically manifests clinically as an isolated amnestic deficit that progresses to a characteristic dementia syndrome. Advances in neuroimaging research have enabled mapping of diverse molecular, functional, and structural aspects of Alzheimer's disease pathology in ever increasing temporal and regional detail. Accumulating evidence suggests that distinct types of imaging abnormalities related to Alzheimer's disease follow a consistent trajectory during pathogenesis of the disease, and that the first changes can be detected years before the disease manifests clinically. These findings have fuelled clinical interest in the use of specific imaging markers for Alzheimer's disease to predict future development of dementia in patients who are at risk. The potential clinical usefulness of single or multimodal imaging markers is being investigated in selected patient samples from clinical expert centres, but additional research is needed before these promising imaging markers can be successfully translated from research into clinical practice in routine care.

Original languageEnglish
Article number73
Pages (from-to)1037-1053
Number of pages17
JournalThe Lancet Neurology
Volume14
Issue number10
DOIs
Publication statusPublished - Oct 1 2015

ASJC Scopus subject areas

  • Clinical Neurology
  • Medicine(all)

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