Multimodal imaging in systemic lupus erythematosus patients with diffuse neuropsychiatric involvement

R. Zivadinov, J. L. Shucard, S. Hussein, J. Durfee, J. L. Cox, N. Bergsland, M. G. Dwyer, R. H B Benedict, J. Ambrus, D. W. Shucard

Research output: Contribution to journalArticle

Abstract

Objectives: The objective of this paper is to investigate conventional and nonconventional brain magnetic resonance imaging (MRI) findings in systemic lupus erythematosus (SLE) patients with diffuse neuropsychiatric involvement (dNPSLE) compared to healthy controls (HCs). Methods: Twenty-six (26) SLE patients with one or more diffuse NP syndromes related to the central nervous system (CNS) (dNPSLE) and 36 age- and sex-matched HCs were scanned on a 3T MRI using a multimodal imaging approach. Univariate and multivariate analyses were used to determine MRI-specific measure differences between dNPSLE and HCs for lesion burden, tissue-specific atrophy, magnetization transfer ratio (MTR) and diffusion-tensor imaging (DTI) outcomes. Results: In univariate analyses, dNPSLE patients showed significantly increased T1 lesion number (p=.001) and T1-lesion volume (LV, p=.008) compared to HCs. dNPSLE patients showed decreased whole brain volume (p2=0.59, p

Original languageEnglish
Pages (from-to)675-683
Number of pages9
JournalLupus
Volume22
Issue number7
DOIs
Publication statusPublished - Jun 2013

Keywords

  • axial and radial diffusivity
  • cortical atrophy
  • diffusion tensor imaging
  • Healthy controls
  • lesion burden
  • magnetization transfer imaging
  • neuropsychiatric systemic lupus erythematosus
  • subcortical atrophy
  • white matter injury

ASJC Scopus subject areas

  • Rheumatology

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  • Cite this

    Zivadinov, R., Shucard, J. L., Hussein, S., Durfee, J., Cox, J. L., Bergsland, N., Dwyer, M. G., Benedict, R. H. B., Ambrus, J., & Shucard, D. W. (2013). Multimodal imaging in systemic lupus erythematosus patients with diffuse neuropsychiatric involvement. Lupus, 22(7), 675-683. https://doi.org/10.1177/0961203313486193