Multimodal Imaging of Vitreoretinal Lymphoma

Chiara Mapelli, Alessandro Invernizzi, Giulio Barteselli, Marco Pellegrini, Elena Tabacchi, Giovanni Staurenghi, Francesco Viola

Research output: Contribution to journalArticlepeer-review


Purpose: To assess the characteristics and prevalence of fundus abnormalities in vitreoretinal lymphoma (VRL) using multimodal imaging. Methods: We retrospectively reviewed chart and imaging studies of patients diagnosed with VRL. Results: All 10 VRL patients (14 eyes) included in the study showed vitreitis, hyperreflective lesions on near-infrared reflectance imaging, and hypoautofluorescent lesions on fundus autofluorescence. Other findings included hypofluorescent lesions on fluorescein angiography (79%), hypocyanescent lesions on indocyanine green angiography (77%), small retinal pigment epithelium detachments (PEDs) (71%) and large PEDs (36%) on optical coherence tomography (OCT). Outer retinal layer nodularity was identified on OCT in 93% of cases. Small PEDs corresponded to hyperreflective, hyperautofluorescent, hypofluorescent, hypocyanescent lesions. Conclusion: Multiple signs were present on multimodal imaging in VRL eyes. Lymphomatous infiltration created focal PEDs showing abnormal imaging signals. Outer retinal layer nodularity could represent an additional sign of infiltration. Multimodal imaging may guide physicians in the early diagnosis of VRL.

Original languageEnglish
Pages (from-to)166-174
Number of pages9
Issue number3
Publication statusPublished - 2016


  • Lymphoma
  • Multimodal imaging
  • Primary intraocular lymphoma
  • Vitreoretinal lymphoma

ASJC Scopus subject areas

  • Ophthalmology
  • Sensory Systems


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