Abstract
| Original language | English |
|---|---|
| Pages (from-to) | 95-104 |
| Number of pages | 10 |
| Journal | Neurobiology of Aging |
| Volume | 62 |
| Issue number | 8 |
| DOIs | |
| Publication status | Published - 2018 |
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Multimodal MRI quantification of the common neurostructural bases within the FTD-ALS continuum. / Crespi, Chiara; Dodich, A; Cappa, SF; Canessa, N; Iannaccone, S; Corbo, M; Lunetta, C; Falini, A; Cerami, C.
In: Neurobiology of Aging, Vol. 62, No. 8, 2018, p. 95-104.Research output: Contribution to journal › Article
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TY - JOUR
T1 - Multimodal MRI quantification of the common neurostructural bases within the FTD-ALS continuum
AU - Crespi, Chiara
AU - Dodich, A
AU - Cappa, SF
AU - Canessa, N
AU - Iannaccone, S
AU - Corbo, M
AU - Lunetta, C
AU - Falini, A
AU - Cerami, C
N1 - QUALCUNO HA CONFIGURATO (DA ADMINISTRATOR DI PURE) UNA IMPORT STRATEGY PER CUI CHIARA CERAMI RISULTA APPARTENERE ALLA FONDAZIONE MAUGERI. IO HO AGGIUNTO MANUALMENTE IL SAN RAFFAELE (Diego)
PY - 2018
Y1 - 2018
N2 - The continuum hypothesis linking the behavioral variant of frontotemporal dementia (bvFTD) and amyotrophic lateral sclerosis (ALS) is supported by clinical, pathological, genetic, and neuroimaging evidence. In the present multimodal magnetic resonance study, we characterized the site and extent of shared neurostructural changes in gray and white matter in 20 bvFTD and 19 ALS patients without dementia. We found an overlap of macrostructural and microstructural damage in both patient groups compared with healthy controls, involving the right orbital and the bilateral anterior cingulate cortices, the corticospinal tract and corpus callosum. The quantification of gray and white matter damage within the areas of shared alterations highlighted a higher degree of atrophy in orbitofrontal and frontomedial regions in patients with more severe executive and/or behavioral symptoms, and a higher degree of degeneration in the motor pathway in patients with more severe motor neuron disorders. Our finding provides additional evidence confirming the FTD-ALS continuum hypothesis and supports the notion of a bimodal but convergent pattern of neurostructural changes characterizing bvFTD and ALS. Copyright © 2017 Elsevier Inc. All rights reserved.
AB - The continuum hypothesis linking the behavioral variant of frontotemporal dementia (bvFTD) and amyotrophic lateral sclerosis (ALS) is supported by clinical, pathological, genetic, and neuroimaging evidence. In the present multimodal magnetic resonance study, we characterized the site and extent of shared neurostructural changes in gray and white matter in 20 bvFTD and 19 ALS patients without dementia. We found an overlap of macrostructural and microstructural damage in both patient groups compared with healthy controls, involving the right orbital and the bilateral anterior cingulate cortices, the corticospinal tract and corpus callosum. The quantification of gray and white matter damage within the areas of shared alterations highlighted a higher degree of atrophy in orbitofrontal and frontomedial regions in patients with more severe executive and/or behavioral symptoms, and a higher degree of degeneration in the motor pathway in patients with more severe motor neuron disorders. Our finding provides additional evidence confirming the FTD-ALS continuum hypothesis and supports the notion of a bimodal but convergent pattern of neurostructural changes characterizing bvFTD and ALS. Copyright © 2017 Elsevier Inc. All rights reserved.
U2 - 10.1016/j.neurobiolaging.2017.09.019
DO - 10.1016/j.neurobiolaging.2017.09.019
M3 - Article
VL - 62
SP - 95
EP - 104
JO - Neurobiology of Aging
JF - Neurobiology of Aging
SN - 0197-4580
IS - 8
ER -