TY - JOUR
T1 - Multimodal pathway for brain tumor-related epilepsy patients
T2 - Observational study
AU - Maialetti, Andrea
AU - Maschio, Marta
AU - Zarabla, Alessia
AU - Polimadei, Camilla
AU - Papa, Elena
AU - Villani, Veronica
AU - Giannarelli, Diana
N1 - Funding Information:
This work was supported by Chiesa Evangelica Valdese (Prot.: 26097/ds/2016‐Uff OPM).
Publisher Copyright:
© 2020 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd
Copyright:
Copyright 2020 Elsevier B.V., All rights reserved.
PY - 2020/6/1
Y1 - 2020/6/1
N2 - Objectives: Brain tumor-related epilepsy patients (BTRE) have a complex profile due to the simultaneous presence of two pathologies: brain tumor and epilepsy. That illness and their treatments could induce physical, cognitive, emotional disturbances, and possible social isolation, with detrimental effect on patients’ quality of life (QoL). Aim of this observational pilot study is to evaluate whether a multimodal rehabilitation pathway (MRP) consisting of epileptological follow-up, neurocognitive training, emotional support, and social support could produce an improvement in perceived quality of life of 33 patients with BTRE. Materials and methods: Basal (T0) and 6 month (T1) evaluation with epileptological, neuropsychological, psychological state (Symptom checklist-SCL-90), social (Social questionnaire schedule-SQS), and QoL assessment (QOLIE 31-P). MRP consisted in epileptological follow-up, supportive meeting groups, social assistance; patients with cognitive deficits could also obtain a 12-week neurocognitive training. Results: We observed at T1 significant improvements in mean seizure/month (P =.02), verbal memory (word list immediate recall, P =.01; word list delayed recall P =.003), social aspects with regard to assistencial network's efficacy (SQS network P =.001) and quality of social relations (SQS socialization P <.0001). QOLIE 31-P showed a significant improvement in cognitive scale (P =.04) and a significant decrease in cognitive related distress (P =.04). No psychopathological symptoms were detected. Conclusion: After 6 months, MRP produced significant improvements in seizure control, cognitive performances, quality of social relations, patients’ perception to be supported and patients’ perceived quality of life related to cognitive efficacy. Future randomized trial with longer follow-up is needed to further evaluate the impact of this kind of pathway on patients’ QoL.
AB - Objectives: Brain tumor-related epilepsy patients (BTRE) have a complex profile due to the simultaneous presence of two pathologies: brain tumor and epilepsy. That illness and their treatments could induce physical, cognitive, emotional disturbances, and possible social isolation, with detrimental effect on patients’ quality of life (QoL). Aim of this observational pilot study is to evaluate whether a multimodal rehabilitation pathway (MRP) consisting of epileptological follow-up, neurocognitive training, emotional support, and social support could produce an improvement in perceived quality of life of 33 patients with BTRE. Materials and methods: Basal (T0) and 6 month (T1) evaluation with epileptological, neuropsychological, psychological state (Symptom checklist-SCL-90), social (Social questionnaire schedule-SQS), and QoL assessment (QOLIE 31-P). MRP consisted in epileptological follow-up, supportive meeting groups, social assistance; patients with cognitive deficits could also obtain a 12-week neurocognitive training. Results: We observed at T1 significant improvements in mean seizure/month (P =.02), verbal memory (word list immediate recall, P =.01; word list delayed recall P =.003), social aspects with regard to assistencial network's efficacy (SQS network P =.001) and quality of social relations (SQS socialization P <.0001). QOLIE 31-P showed a significant improvement in cognitive scale (P =.04) and a significant decrease in cognitive related distress (P =.04). No psychopathological symptoms were detected. Conclusion: After 6 months, MRP produced significant improvements in seizure control, cognitive performances, quality of social relations, patients’ perception to be supported and patients’ perceived quality of life related to cognitive efficacy. Future randomized trial with longer follow-up is needed to further evaluate the impact of this kind of pathway on patients’ QoL.
KW - brain tumor-related epilepsy (BTRE)
KW - multimodal approach
KW - quality of life
KW - rehabilitation
KW - social relations
KW - supportive network
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U2 - 10.1111/ane.13228
DO - 10.1111/ane.13228
M3 - Article
C2 - 32043558
AN - SCOPUS:85080049671
VL - 141
SP - 450
EP - 462
JO - Acta Neurologica Scandinavica
JF - Acta Neurologica Scandinavica
SN - 0001-6314
IS - 6
ER -