Multimodal sequential approach in colorectal cancer liver metastases: Hepatic resection after yttrium-90 selective internal radiation therapy and cetuximab rescue treatment

Sara Pini, Carmine Pinto, Bruna Angelelli, Emanuela Giampalma, Annabella Blotta, Francesca Di Fabio, Donatella Santini, Rita Golfieri, Andrea Angelo Martoni

Research output: Contribution to journalArticle

Abstract

Synchronous or metachronous liver metastases occur in up to one-third of patients with colorectal cancer and are associated with a poor prognosis. Many evidences have shown that surgical resection can be curative, with 5-year survival rates ranging from37% to 50%, butmany patients are ineligible for surgery because ofmultiple liver lesions, bilobar distribution of liver metastases, or the presence of widespread extrahepatic disease. The management of unresectable liver metastases includes many therapeutic options such as systemic chemotherapy, selective internal radiation therapy (SIRT) with yttrium-90 (Y-90), targeted therapy, and surgery. These treatments can be integrated into a sequential multimodal approach to increase the resection rate.We present a case in which such an approach was put into practice. The favorable result suggests that SIRT, along with systemic chemotherapy and surgery, is a valid treatment option for unresectable colorectal liver metastases. Free full text available at www.tumorionline.it.

Original languageEnglish
Pages (from-to)157-159
Number of pages3
JournalTumori
Volume96
Issue number1
DOIs
Publication statusPublished - Jan 2010

Keywords

  • Colorectal cancer liver metastases
  • Selective internal radiation therapy
  • Yttrium-90

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

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