Multimodal treatment of distal sensorimotor polyneuropathy in diabetic patients: A randomized clinical trial

Giovanni Taveggia, Jorge H. Villafañe, Francesca Vavassori, Cristina Lecchi, Alberto Borboni, Stefano Negrini

Research output: Contribution to journalArticlepeer-review


Objective The purpose of this study was to evaluate the effectiveness of the application of analyzing treadmill, muscle strengthening, and balance training compared with a standard care intervention in patients with diabetic neuropathy. Methods Twenty-seven patients, 63% female (mean ± standard deviations age, 72 ± 9 years), with diabetic neuropathy randomly assigned to receive a multimodal manual treatment approach including analyzing treadmill with feedback focused, isokinetic dynamometric muscle strengthening, and balance retraining on dynamic balance platform or a standard care intervention for activities targeted to improve endurance, manual exercises of muscle strengthening, stretching exercises, gait, and balance exercises (5 weekly over 4 weeks). This study was designed as a double-blind, randomized clinical trial. Measures were assessed at pretreatment, 4 weeks posttreatment, and 2-month follow-up. Results No important baseline differences were observed between groups. At the end of the treatment period, the experimental group showed a significant increase in gait endurance in a 6-minute walk test, 65.6 m (F [2.0] = 9.636; P =.001). In addition, the 6-minute walk test increased after the intervention, and an even greater difference was found at follow-up (P =.005) for the standard care group. The Functional Independence Measure in both groups increased (P

Original languageEnglish
Pages (from-to)242-252
Number of pages11
JournalJournal of Manipulative and Physiological Therapeutics
Issue number4
Publication statusPublished - 2014


  • Gait Disorders
  • Muscle Strength
  • Neuropathy
  • Walking

ASJC Scopus subject areas

  • Chiropractics
  • Medicine(all)


Dive into the research topics of 'Multimodal treatment of distal sensorimotor polyneuropathy in diabetic patients: A randomized clinical trial'. Together they form a unique fingerprint.

Cite this