Multimodal Voxel-Based Meta-Analysis of White Matter Abnormalities in Alzheimer's 13422Disease

Rui Hua Yin, Lan Tan, Yong Liu, Wen Ying Wang, Hui Fu Wang, Teng Jiang, Joaquim Radua, Yu Zhang, Junling Gao, Elisa Canu, Raffaella Migliaccio, Massimo Filippi, Maria Luisa Gorno-Tempini, Jin Tai Yu

Research output: Contribution to journalArticlepeer-review


An increasing number of MRI investigations suggest that patients with Alzheimer's disease (AD) show not only gray matter decreases but also white matter (WM) abnormalities, including WM volume (WMV) deficits and integrity disruption of WM pathways. In this study, we applied multimodal voxel-wise meta-analytical methods to study WMV and fractional anisotropy in AD. Fourteen studies including 723 participants (340 with AD and 383 controls) were involved. The meta-analysis was performed using effect size signed differential mapping. Significant WMV reductions were observed in bilateral inferior temporal gyrus, splenium of corpus callosum, right parahippocampal gyrus, and hippocampus. Decreased fractional anisotropy was identified mainly in left posterior limb of internal capsule, left anterior corona radiata, left thalamus, and left caudate nucleus. Significant decreases of both WMV and fractional anisotropy were found in left caudate nucleus, left superior corona radiata, and right inferior temporal gyrus. Most findings showed to be highly replicable in the jackknife sensitivity analyses. In conclusion, AD patients show widespread WM abnormalities mainly in bilateral structures related to advanced mental and nervous activities.

Original languageEnglish
Pages (from-to)495-507
Number of pages13
JournalJournal of Alzheimer's Disease
Issue number2
Publication statusPublished - Jul 24 2015


  • Alzheimer's disease
  • diffusion tension imaging
  • fractional anisotropy
  • magnetic resonance imaging
  • voxel-based morphometry
  • white matter

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Geriatrics and Gerontology
  • Clinical Psychology


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