Multimodality imaging in pulmonary hypertension

Eduardo Bossone, Santo Dellegrottaglie, Smita Patel, Ekkehard Grunig, Antonello D'Andrea, Francesco Ferrara, Paola Gargiulo, Michele D'Alto, Andrea Soricelli, Antonio Cittadini, Javier Sanz, Pasquale Perrone-Filardi, Melvyn Rubenfire

Research output: Contribution to journalArticlepeer-review


Pulmonary hypertension (PH) is a pathophysiological condition defined as an increase in mean pulmonary artery pressure of ≥ 25 mm Hg at rest. Although right heart catheterization remains an essential step in the diagnostic algorithm-particularly for pulmonary arterial hypertension-noninvasive multimodality imaging plays an important role in defining the cause, assessing outcome, monitoring the efficacy of specific therapeutic interventions, and detecting the preclinical stage of disease. We review the role of multimodality imaging in the evaluation of PH-including echocardiography, chest computed tomography, cardiovascular magnetic resonance imaging, and nuclear imaging-the choice of which depends on individual patient-based indications provided by the clinical team in accordance with current guidelines, also taking into account institutional expertise, patient safety and convenience, and repeatability. Recent advances in cardiac imaging (3-dimensional echocardiography and strain imaging, tissue characterization, and 18F-fluorodeoxyglucose positron emission tomography) may provide new insights into the pathophysiological characteristics of the right heart-pulmonary circulation unit.

Original languageEnglish
Pages (from-to)440-459
Number of pages20
JournalCanadian Journal of Cardiology
Issue number4
Publication statusPublished - Apr 1 2015

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine


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