Multimodality imaging of adult rhabdomyosarcoma: the added value of hybrid imaging

Nicolò Gennaro; Andrea Marrari; Salvatore Lorenzo Renne; Ferdinando Carlo Maria Cananzi; Vittorio Lorenzo Quagliuolo; Lucia Di Brina; Marta Scorsetti; Giovanna Pepe; Arturo Chiti; Armando Santoro; Luca Balzarini; Letterio Salvatore Politi; Alexia Francesca Bertuzzi

doi:10.1259/bjr.20200250

Multimodality imaging of adult rhabdomyosarcoma: the added value of hybrid imaging

Nicolò Gennaro, Andrea Marrari, Salvatore Lorenzo Renne, Ferdinando Carlo Maria Cananzi, Vittorio Lorenzo Quagliuolo, Lucia Di Brina, Marta Scorsetti, Giovanna Pepe, Arturo Chiti, Armando Santoro, Luca Balzarini, Letterio Salvatore Politi, Alexia Francesca Bertuzzi

Istituto Clinico Humanitas

Research output: Contribution to journal › Review article › peer-review

Abstract

Rhabdomyosarcoma (RMS) represents more than 50% of paediatric soft tissue tumours. Conversely, it is extremely rare among adults, where it shows peculiar biological and clinical features that are still poorly investigated. RMS patients should be referred to a Sarcoma Centre, where the contribution of experienced radiologists plays a relevant role in the diagnostic assessment of the disease, including precise localisation, staging, image-guided biopsy, response evaluation after treatment and follow-up. Besides CT and MRI, hybrid imaging including positron emission tomography (PET)/CT and PET/MRI are giving an increasing contribution to provide functional insights about tumour biology and to improve the diagnostic accuracy of the imaging work-up. This review paper provides a revision of the pathology, clinical and radiological features of adult RMS, with a particular focus on the growing role of hybrid PET-based imaging.

Original language	English
Pages (from-to)	20200250
Journal	The British journal of radiology
Volume	93
Issue number	1112
DOIs	https://doi.org/10.1259/bjr.20200250
Publication status	Published - Aug 2020

Keywords

Humans
Magnetic Resonance Imaging
Multimodal Imaging/methods
Positron Emission Tomography Computed Tomography
Rhabdomyosarcoma/diagnostic imaging
Soft Tissue Neoplasms/diagnostic imaging
Tomography, X-Ray Computed

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Gennaro, N., Marrari, A., Renne, S. L., Cananzi, F. C. M., Quagliuolo, V. L., Di Brina, L., Scorsetti, M., Pepe, G., Chiti, A., Santoro, A., Balzarini, L., Politi, L. S., & Bertuzzi, A. F. (2020). Multimodality imaging of adult rhabdomyosarcoma: the added value of hybrid imaging. The British journal of radiology, 93(1112), 20200250. https://doi.org/10.1259/bjr.20200250

Multimodality imaging of adult rhabdomyosarcoma : the added value of hybrid imaging. / Gennaro, Nicolò; Marrari, Andrea ; Renne, Salvatore Lorenzo ; Cananzi, Ferdinando Carlo Maria ; Quagliuolo, Vittorio Lorenzo; Di Brina, Lucia; Scorsetti, Marta ; Pepe, Giovanna ; Chiti, Arturo ; Santoro, Armando ; Balzarini, Luca; Politi, Letterio Salvatore; Bertuzzi, Alexia Francesca.

In: The British journal of radiology, Vol. 93, No. 1112, 08.2020, p. 20200250.

Research output: Contribution to journal › Review article › peer-review

Gennaro, Nicolò ; Marrari, Andrea ; Renne, Salvatore Lorenzo ; Cananzi, Ferdinando Carlo Maria ; Quagliuolo, Vittorio Lorenzo ; Di Brina, Lucia ; Scorsetti, Marta ; Pepe, Giovanna ; Chiti, Arturo ; Santoro, Armando ; Balzarini, Luca ; Politi, Letterio Salvatore ; Bertuzzi, Alexia Francesca. / Multimodality imaging of adult rhabdomyosarcoma : the added value of hybrid imaging. In: The British journal of radiology. 2020 ; Vol. 93, No. 1112. pp. 20200250.

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abstract = "Rhabdomyosarcoma (RMS) represents more than 50% of paediatric soft tissue tumours. Conversely, it is extremely rare among adults, where it shows peculiar biological and clinical features that are still poorly investigated. RMS patients should be referred to a Sarcoma Centre, where the contribution of experienced radiologists plays a relevant role in the diagnostic assessment of the disease, including precise localisation, staging, image-guided biopsy, response evaluation after treatment and follow-up. Besides CT and MRI, hybrid imaging including positron emission tomography (PET)/CT and PET/MRI are giving an increasing contribution to provide functional insights about tumour biology and to improve the diagnostic accuracy of the imaging work-up. This review paper provides a revision of the pathology, clinical and radiological features of adult RMS, with a particular focus on the growing role of hybrid PET-based imaging.",

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AU - Scorsetti, Marta

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AU - Bertuzzi, Alexia Francesca

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AB - Rhabdomyosarcoma (RMS) represents more than 50% of paediatric soft tissue tumours. Conversely, it is extremely rare among adults, where it shows peculiar biological and clinical features that are still poorly investigated. RMS patients should be referred to a Sarcoma Centre, where the contribution of experienced radiologists plays a relevant role in the diagnostic assessment of the disease, including precise localisation, staging, image-guided biopsy, response evaluation after treatment and follow-up. Besides CT and MRI, hybrid imaging including positron emission tomography (PET)/CT and PET/MRI are giving an increasing contribution to provide functional insights about tumour biology and to improve the diagnostic accuracy of the imaging work-up. This review paper provides a revision of the pathology, clinical and radiological features of adult RMS, with a particular focus on the growing role of hybrid PET-based imaging.

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KW - Magnetic Resonance Imaging

KW - Multimodal Imaging/methods

KW - Positron Emission Tomography Computed Tomography

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KW - Tomography, X-Ray Computed

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