Multiparametric electrocardiographic evaluation of left ventricular hypertrophy in idiopathic and hypertensive cardiomyopathy

Chiara Lazzeri, Giuseppe Barletta, Toni Badia, Andrea Capalbio, Riccarda Del Bene, Franco Franchi, Gian Franco Gensini, Antonio Michelucci

Research output: Contribution to journalArticle

Abstract

Background. Electrophysiological abnormalitieS underlying the increased arrhymogenicity of ventricular hypertrophy (LVH) are still under investigation. The aim of this study was to assess non-invasively the electrophysiologic alterations in two different types of LVH, Methods. Multiparametric non-invasive ECG analysis (R-R interval, QRS and QT intervals, QT dispersion, T-wave complexity, activation-recovery interval [ARI] dispersion, standard deviation of RR intervals [SDNN], filtered QRS duration [fQRS], root-mean-square voltage of the terminal 40 ms of the fQRS [RMS] and low amplitude signal duration (<40 μV) in the terminal portion of the fQRS [LAS]) was performed in 57 patients with hypertensive LVH and hypertrophic cardiomyopathy (HCM), and in 105 healthy subjects. Results. The R-R interval and SDNN were similar in hypertrophic patients and controls. QRS and QT intervals were longer in hypertrophic patients without any differences between hypertensive LVH and HCM. QT dispersion, T-wave complexity and fQRS were greater in hypertrophic patients; QT dispersion was the greatest in HCM. ARI dispersion was lesser in hypertrophic patients without any differences between subgroups of LVH. fQRS showed a trend toward higher values in hypertensive patients. LAS at 25 Hz had a trend toward lower values in HCM patients, while LAS at 40 Hz and RMS40 showed no difference between controls and hypertrophic patients. Left ventricular mass index was not correlated with any of the above-mentioned parameters. Conclusions. The QT interval and dispersion did not identify the type of hypertrophy. Similarly, ARI dispersion which explores local variations of repolarization duration, and T-wave complexity could not distinguish patients with hypertensive LVII from those with HCM indicating that multi parametric ECG data are affected more by the presence of LVH, than by its type.

Original languageEnglish
Pages (from-to)304-310
Number of pages7
JournalItalian Heart Journal
Volume6
Issue number4
Publication statusPublished - Apr 2005

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Left Ventricular Hypertrophy
Cardiomyopathies
Hypertrophic Cardiomyopathy
Hypertrophy
Electrocardiography
Healthy Volunteers

Keywords

  • Electrocardiography
  • Heart rate variability
  • Hypertrophic cardiomyopathy
  • Left ventricular hypertrophy
  • QT interval

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Lazzeri, C., Barletta, G., Badia, T., Capalbio, A., Del Bene, R., Franchi, F., ... Michelucci, A. (2005). Multiparametric electrocardiographic evaluation of left ventricular hypertrophy in idiopathic and hypertensive cardiomyopathy. Italian Heart Journal, 6(4), 304-310.

Multiparametric electrocardiographic evaluation of left ventricular hypertrophy in idiopathic and hypertensive cardiomyopathy. / Lazzeri, Chiara; Barletta, Giuseppe; Badia, Toni; Capalbio, Andrea; Del Bene, Riccarda; Franchi, Franco; Gensini, Gian Franco; Michelucci, Antonio.

In: Italian Heart Journal, Vol. 6, No. 4, 04.2005, p. 304-310.

Research output: Contribution to journalArticle

Lazzeri, C, Barletta, G, Badia, T, Capalbio, A, Del Bene, R, Franchi, F, Gensini, GF & Michelucci, A 2005, 'Multiparametric electrocardiographic evaluation of left ventricular hypertrophy in idiopathic and hypertensive cardiomyopathy', Italian Heart Journal, vol. 6, no. 4, pp. 304-310.
Lazzeri C, Barletta G, Badia T, Capalbio A, Del Bene R, Franchi F et al. Multiparametric electrocardiographic evaluation of left ventricular hypertrophy in idiopathic and hypertensive cardiomyopathy. Italian Heart Journal. 2005 Apr;6(4):304-310.
Lazzeri, Chiara ; Barletta, Giuseppe ; Badia, Toni ; Capalbio, Andrea ; Del Bene, Riccarda ; Franchi, Franco ; Gensini, Gian Franco ; Michelucci, Antonio. / Multiparametric electrocardiographic evaluation of left ventricular hypertrophy in idiopathic and hypertensive cardiomyopathy. In: Italian Heart Journal. 2005 ; Vol. 6, No. 4. pp. 304-310.
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abstract = "Background. Electrophysiological abnormalitieS underlying the increased arrhymogenicity of ventricular hypertrophy (LVH) are still under investigation. The aim of this study was to assess non-invasively the electrophysiologic alterations in two different types of LVH, Methods. Multiparametric non-invasive ECG analysis (R-R interval, QRS and QT intervals, QT dispersion, T-wave complexity, activation-recovery interval [ARI] dispersion, standard deviation of RR intervals [SDNN], filtered QRS duration [fQRS], root-mean-square voltage of the terminal 40 ms of the fQRS [RMS] and low amplitude signal duration (<40 μV) in the terminal portion of the fQRS [LAS]) was performed in 57 patients with hypertensive LVH and hypertrophic cardiomyopathy (HCM), and in 105 healthy subjects. Results. The R-R interval and SDNN were similar in hypertrophic patients and controls. QRS and QT intervals were longer in hypertrophic patients without any differences between hypertensive LVH and HCM. QT dispersion, T-wave complexity and fQRS were greater in hypertrophic patients; QT dispersion was the greatest in HCM. ARI dispersion was lesser in hypertrophic patients without any differences between subgroups of LVH. fQRS showed a trend toward higher values in hypertensive patients. LAS at 25 Hz had a trend toward lower values in HCM patients, while LAS at 40 Hz and RMS40 showed no difference between controls and hypertrophic patients. Left ventricular mass index was not correlated with any of the above-mentioned parameters. Conclusions. The QT interval and dispersion did not identify the type of hypertrophy. Similarly, ARI dispersion which explores local variations of repolarization duration, and T-wave complexity could not distinguish patients with hypertensive LVII from those with HCM indicating that multi parametric ECG data are affected more by the presence of LVH, than by its type.",
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AU - Lazzeri, Chiara

AU - Barletta, Giuseppe

AU - Badia, Toni

AU - Capalbio, Andrea

AU - Del Bene, Riccarda

AU - Franchi, Franco

AU - Gensini, Gian Franco

AU - Michelucci, Antonio

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N2 - Background. Electrophysiological abnormalitieS underlying the increased arrhymogenicity of ventricular hypertrophy (LVH) are still under investigation. The aim of this study was to assess non-invasively the electrophysiologic alterations in two different types of LVH, Methods. Multiparametric non-invasive ECG analysis (R-R interval, QRS and QT intervals, QT dispersion, T-wave complexity, activation-recovery interval [ARI] dispersion, standard deviation of RR intervals [SDNN], filtered QRS duration [fQRS], root-mean-square voltage of the terminal 40 ms of the fQRS [RMS] and low amplitude signal duration (<40 μV) in the terminal portion of the fQRS [LAS]) was performed in 57 patients with hypertensive LVH and hypertrophic cardiomyopathy (HCM), and in 105 healthy subjects. Results. The R-R interval and SDNN were similar in hypertrophic patients and controls. QRS and QT intervals were longer in hypertrophic patients without any differences between hypertensive LVH and HCM. QT dispersion, T-wave complexity and fQRS were greater in hypertrophic patients; QT dispersion was the greatest in HCM. ARI dispersion was lesser in hypertrophic patients without any differences between subgroups of LVH. fQRS showed a trend toward higher values in hypertensive patients. LAS at 25 Hz had a trend toward lower values in HCM patients, while LAS at 40 Hz and RMS40 showed no difference between controls and hypertrophic patients. Left ventricular mass index was not correlated with any of the above-mentioned parameters. Conclusions. The QT interval and dispersion did not identify the type of hypertrophy. Similarly, ARI dispersion which explores local variations of repolarization duration, and T-wave complexity could not distinguish patients with hypertensive LVII from those with HCM indicating that multi parametric ECG data are affected more by the presence of LVH, than by its type.

AB - Background. Electrophysiological abnormalitieS underlying the increased arrhymogenicity of ventricular hypertrophy (LVH) are still under investigation. The aim of this study was to assess non-invasively the electrophysiologic alterations in two different types of LVH, Methods. Multiparametric non-invasive ECG analysis (R-R interval, QRS and QT intervals, QT dispersion, T-wave complexity, activation-recovery interval [ARI] dispersion, standard deviation of RR intervals [SDNN], filtered QRS duration [fQRS], root-mean-square voltage of the terminal 40 ms of the fQRS [RMS] and low amplitude signal duration (<40 μV) in the terminal portion of the fQRS [LAS]) was performed in 57 patients with hypertensive LVH and hypertrophic cardiomyopathy (HCM), and in 105 healthy subjects. Results. The R-R interval and SDNN were similar in hypertrophic patients and controls. QRS and QT intervals were longer in hypertrophic patients without any differences between hypertensive LVH and HCM. QT dispersion, T-wave complexity and fQRS were greater in hypertrophic patients; QT dispersion was the greatest in HCM. ARI dispersion was lesser in hypertrophic patients without any differences between subgroups of LVH. fQRS showed a trend toward higher values in hypertensive patients. LAS at 25 Hz had a trend toward lower values in HCM patients, while LAS at 40 Hz and RMS40 showed no difference between controls and hypertrophic patients. Left ventricular mass index was not correlated with any of the above-mentioned parameters. Conclusions. The QT interval and dispersion did not identify the type of hypertrophy. Similarly, ARI dispersion which explores local variations of repolarization duration, and T-wave complexity could not distinguish patients with hypertensive LVII from those with HCM indicating that multi parametric ECG data are affected more by the presence of LVH, than by its type.

KW - Electrocardiography

KW - Heart rate variability

KW - Hypertrophic cardiomyopathy

KW - Left ventricular hypertrophy

KW - QT interval

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