Multiparametric evaluation by simultaneous PET-MRI examination in patients with histologically proven laryngeal cancer

Carlo Cavaliere, Valeria Romeo, Marco Aiello, Massimo Mesolella, Brigida Iorio, Luigi Barbuto, Elena Cantone, Emanuele Nicolai, Mario Covello

Research output: Contribution to journalArticle

Abstract

Objectives To evaluate the relationship between metabolic 18Fluoro-Deoxyglucose-Positron Emission Tomography (18FDG/PET) and morpho-functional parameters derived by Magnetic Resonance Imaging (MRI) in patients with histologically proven laryngeal cancer. To assess the clinical impact of PET/MRI examination on patient's staging and treatment planning. Methods 16 patients with histologically proven laryngeal cancer were enrolled and underwent whole body PET/CT followed by a dedicated PET/MRI of the head/neck region. Data were separately evaluated by two blinded groups: metabolic (SUV and MTV), diffusion (ADC) and perfusion (Ktrans, Ve, kep and iAUC) maps were obtained by positioning regions of interest (ROIs). Tumoral local extension assessed on PET/MRI was compared to endoscopic findings. Results A good inter-observer agreement was found in anatomical location and local extension of PET/MRI lesions (Cohen's kappa 0.9). PET/CT SUV measures highly correlate with ones derived by PET/MRI (e.g., p = 0.96 for measures on VOI). Significant correlations among metabolic, diffusion and perfusion parameters have been detected. PET/MRI had a relevant clinical impact, confirming endoscopic findings (6 cases), helping treatment planning (9 cases), and modifying endoscopic primary staging (1 case). Conclusions PET/MRI is useful for primary staging of laryngeal cancer, allowing simultaneous collection of metabolic and functional data and conditioning the therapeutic strategies.

Original languageEnglish
Pages (from-to)47-55
Number of pages9
JournalEuropean Journal of Radiology
Volume88
DOIs
Publication statusPublished - Mar 1 2017

Fingerprint

Laryngeal Neoplasms
Magnetic Resonance Imaging
Perfusion
Deoxyglucose
Positron-Emission Tomography
Neck
Therapeutics
Head

Keywords

  • Laryngeal cancer
  • Magnetic resonance imaging
  • PET/MRI
  • Positron emission tomography

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

Cite this

Multiparametric evaluation by simultaneous PET-MRI examination in patients with histologically proven laryngeal cancer. / Cavaliere, Carlo; Romeo, Valeria; Aiello, Marco; Mesolella, Massimo; Iorio, Brigida; Barbuto, Luigi; Cantone, Elena; Nicolai, Emanuele; Covello, Mario.

In: European Journal of Radiology, Vol. 88, 01.03.2017, p. 47-55.

Research output: Contribution to journalArticle

Cavaliere, Carlo ; Romeo, Valeria ; Aiello, Marco ; Mesolella, Massimo ; Iorio, Brigida ; Barbuto, Luigi ; Cantone, Elena ; Nicolai, Emanuele ; Covello, Mario. / Multiparametric evaluation by simultaneous PET-MRI examination in patients with histologically proven laryngeal cancer. In: European Journal of Radiology. 2017 ; Vol. 88. pp. 47-55.
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AU - Iorio, Brigida

AU - Barbuto, Luigi

AU - Cantone, Elena

AU - Nicolai, Emanuele

AU - Covello, Mario

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N2 - Objectives To evaluate the relationship between metabolic 18Fluoro-Deoxyglucose-Positron Emission Tomography (18FDG/PET) and morpho-functional parameters derived by Magnetic Resonance Imaging (MRI) in patients with histologically proven laryngeal cancer. To assess the clinical impact of PET/MRI examination on patient's staging and treatment planning. Methods 16 patients with histologically proven laryngeal cancer were enrolled and underwent whole body PET/CT followed by a dedicated PET/MRI of the head/neck region. Data were separately evaluated by two blinded groups: metabolic (SUV and MTV), diffusion (ADC) and perfusion (Ktrans, Ve, kep and iAUC) maps were obtained by positioning regions of interest (ROIs). Tumoral local extension assessed on PET/MRI was compared to endoscopic findings. Results A good inter-observer agreement was found in anatomical location and local extension of PET/MRI lesions (Cohen's kappa 0.9). PET/CT SUV measures highly correlate with ones derived by PET/MRI (e.g., p = 0.96 for measures on VOI). Significant correlations among metabolic, diffusion and perfusion parameters have been detected. PET/MRI had a relevant clinical impact, confirming endoscopic findings (6 cases), helping treatment planning (9 cases), and modifying endoscopic primary staging (1 case). Conclusions PET/MRI is useful for primary staging of laryngeal cancer, allowing simultaneous collection of metabolic and functional data and conditioning the therapeutic strategies.

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