Multiparametric microfluidic chips for studying cellular pathways

Robert D. Lovchik, Fabio Bianco, Michela Matteoli, Emmanuel Delamarche

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

We present a microfluidic device for studying cellular pathways. The device consists of a poly(dimethylsiloxane) (PDMS) microfluidic network sealed with a Si chip. It comprises two cell chambers, individually addressable through microchannels. Local cell deposition is performed using an efficient, yet simple method based on flow velocity boundaries. A demonstration of the applicability for cellular pathway studies is given by visualizing flow combinations like plug flows and gradients using colored liquids. One important use of this device will be the identification of (bio)chemicals in cellular pathways of the central nervous system, for better understanding their role in brain diseases.

Original languageEnglish
Title of host publicationProceedings of Conference, MicroTAS 2009 - The 13th International Conference on Miniaturized Systems for Chemistry and Life Sciences
PublisherChemical and Biological Microsystems Society
Pages591-593
Number of pages3
ISBN (Print)9780979806421
Publication statusPublished - 2009
Event13th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2009 - Jeju, Korea, Republic of
Duration: Nov 1 2009Nov 5 2009

Other

Other13th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2009
CountryKorea, Republic of
CityJeju
Period11/1/0911/5/09

Keywords

  • Brain disease
  • Cells
  • Microfluidics

ASJC Scopus subject areas

  • Chemical Engineering (miscellaneous)
  • Bioengineering

Fingerprint Dive into the research topics of 'Multiparametric microfluidic chips for studying cellular pathways'. Together they form a unique fingerprint.

  • Cite this

    Lovchik, R. D., Bianco, F., Matteoli, M., & Delamarche, E. (2009). Multiparametric microfluidic chips for studying cellular pathways. In Proceedings of Conference, MicroTAS 2009 - The 13th International Conference on Miniaturized Systems for Chemistry and Life Sciences (pp. 591-593). Chemical and Biological Microsystems Society.