Multiparametric prognostic scores in chronic heart failure with reduced ejection fraction

Piergiuseppe Agostoni, Stefania Paolillo, Massimo Mapelli, Piero Gentile, Elisabetta Salvioni, Fabrizio Veglia, Alice Bonomi, Ugo Corrà, Rocco Lagioia, Giuseppe Limongelli, Gianfranco Sinagra, Gaia Cattadori, Angela B Scardovi, Marco Metra, Valentina Carubelli, Domenico Scrutinio, Rosa Raimondo, Michele Emdin, Massimo Piepoli, Damiano MagrìGianfranco Parati, Sergio Caravita, Federica Re, Mariantonietta Cicoira, Chiara Minà, Michele Correale, Maria Frigerio, Maurizio Bussotti, Fabrizio Oliva, Elisa Battaia, Romualdo Belardinelli, Alessandro Mezzani, Luigi Pastormerlo, Marco Guazzi, Roberto Badagliacca, Andrea Di Lenarda, Claudio Passino, Susanna Sciomer, Elena Zambon, Giuseppe Pacileo, Roberto Ricci, Anna Apostolo, Pietro Palermo, Mauro Contini, Francesco Clemenza, Giovanni Marchese, Paola Gargiulo, Simone Binno, Carlo Lombardi, Andrea Passantino, Pasquale Perrone Filardi

Research output: Contribution to journalArticle

Abstract

AIMS: Risk stratification in heart failure (HF) is crucial for clinical and therapeutic management. A multiparametric approach is the best method to stratify prognosis. In 2012, the Metabolic Exercise test data combined with Cardiac and Kidney Indexes (MECKI) score was proposed to assess the risk of cardiovascular mortality and urgent heart transplantation. The aim of the present study was to compare the prognostic accuracy of MECKI score to that of HF Survival Score (HFSS) and Seattle HF Model (SHFM) in a large, multicentre cohort of HF patients with reduced ejection fraction.METHODS AND RESULTS: We collected data on 6112 HF patients and compared the prognostic accuracy of MECKI score, HFSS, and SHFM at 2- and 4-year follow-up for the combined endpoint of cardiovascular death, urgent cardiac transplantation, or ventricular assist device implantation. Patients were followed up for a median of 3.67 years, and 931 cardiovascular deaths, 160 urgent heart transplantations, and 12 ventricular assist device implantations were recorded. At 2-year follow-up, the prognostic accuracy of MECKI score was significantly superior [area under the curve (AUC) 0.781] to that of SHFM (AUC 0.739) and HFSS (AUC 0.723), and this relationship was also confirmed at 4 years (AUC 0.764, 0.725, and 0.720, respectively).CONCLUSION: In this cohort, the prognostic accuracy of the MECKI score was superior to that of HFSS and SHFM at 2- and 4-year follow-up in HF patients in stable clinical condition. The MECKI score may be useful to improve resource allocation and patient outcome, but prospective evaluation is needed.
Original languageItalian
JournalEuropean Journal of Heart Failure
DOIs
Publication statusPublished - 2018

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Multiparametric prognostic scores in chronic heart failure with reduced ejection fraction. / Agostoni, Piergiuseppe; Paolillo, Stefania; Mapelli, Massimo; Gentile, Piero; Salvioni, Elisabetta; Veglia, Fabrizio; Bonomi, Alice; Corrà, Ugo; Lagioia, Rocco; Limongelli, Giuseppe; Sinagra, Gianfranco; Cattadori, Gaia; Scardovi, Angela B; Metra, Marco; Carubelli, Valentina; Scrutinio, Domenico; Raimondo, Rosa; Emdin, Michele; Piepoli, Massimo; Magrì, Damiano; Parati, Gianfranco; Caravita, Sergio; Re, Federica; Cicoira, Mariantonietta; Minà, Chiara; Correale, Michele; Frigerio, Maria; Bussotti, Maurizio; Oliva, Fabrizio; Battaia, Elisa; Belardinelli, Romualdo; Mezzani, Alessandro; Pastormerlo, Luigi; Guazzi, Marco; Badagliacca, Roberto; Di Lenarda, Andrea; Passino, Claudio; Sciomer, Susanna; Zambon, Elena; Pacileo, Giuseppe; Ricci, Roberto; Apostolo, Anna; Palermo, Pietro; Contini, Mauro; Clemenza, Francesco; Marchese, Giovanni; Gargiulo, Paola; Binno, Simone; Lombardi, Carlo; Passantino, Andrea; Filardi, Pasquale Perrone.

In: European Journal of Heart Failure, 2018.

Research output: Contribution to journalArticle

Agostoni, P, Paolillo, S, Mapelli, M, Gentile, P, Salvioni, E, Veglia, F, Bonomi, A, Corrà, U, Lagioia, R, Limongelli, G, Sinagra, G, Cattadori, G, Scardovi, AB, Metra, M, Carubelli, V, Scrutinio, D, Raimondo, R, Emdin, M, Piepoli, M, Magrì, D, Parati, G, Caravita, S, Re, F, Cicoira, M, Minà, C, Correale, M, Frigerio, M, Bussotti, M, Oliva, F, Battaia, E, Belardinelli, R, Mezzani, A, Pastormerlo, L, Guazzi, M, Badagliacca, R, Di Lenarda, A, Passino, C, Sciomer, S, Zambon, E, Pacileo, G, Ricci, R, Apostolo, A, Palermo, P, Contini, M, Clemenza, F, Marchese, G, Gargiulo, P, Binno, S, Lombardi, C, Passantino, A & Filardi, PP 2018, 'Multiparametric prognostic scores in chronic heart failure with reduced ejection fraction', European Journal of Heart Failure. https://doi.org/10.1002/ejhf.989
Agostoni, Piergiuseppe ; Paolillo, Stefania ; Mapelli, Massimo ; Gentile, Piero ; Salvioni, Elisabetta ; Veglia, Fabrizio ; Bonomi, Alice ; Corrà, Ugo ; Lagioia, Rocco ; Limongelli, Giuseppe ; Sinagra, Gianfranco ; Cattadori, Gaia ; Scardovi, Angela B ; Metra, Marco ; Carubelli, Valentina ; Scrutinio, Domenico ; Raimondo, Rosa ; Emdin, Michele ; Piepoli, Massimo ; Magrì, Damiano ; Parati, Gianfranco ; Caravita, Sergio ; Re, Federica ; Cicoira, Mariantonietta ; Minà, Chiara ; Correale, Michele ; Frigerio, Maria ; Bussotti, Maurizio ; Oliva, Fabrizio ; Battaia, Elisa ; Belardinelli, Romualdo ; Mezzani, Alessandro ; Pastormerlo, Luigi ; Guazzi, Marco ; Badagliacca, Roberto ; Di Lenarda, Andrea ; Passino, Claudio ; Sciomer, Susanna ; Zambon, Elena ; Pacileo, Giuseppe ; Ricci, Roberto ; Apostolo, Anna ; Palermo, Pietro ; Contini, Mauro ; Clemenza, Francesco ; Marchese, Giovanni ; Gargiulo, Paola ; Binno, Simone ; Lombardi, Carlo ; Passantino, Andrea ; Filardi, Pasquale Perrone. / Multiparametric prognostic scores in chronic heart failure with reduced ejection fraction. In: European Journal of Heart Failure. 2018.
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abstract = "AIMS: Risk stratification in heart failure (HF) is crucial for clinical and therapeutic management. A multiparametric approach is the best method to stratify prognosis. In 2012, the Metabolic Exercise test data combined with Cardiac and Kidney Indexes (MECKI) score was proposed to assess the risk of cardiovascular mortality and urgent heart transplantation. The aim of the present study was to compare the prognostic accuracy of MECKI score to that of HF Survival Score (HFSS) and Seattle HF Model (SHFM) in a large, multicentre cohort of HF patients with reduced ejection fraction.METHODS AND RESULTS: We collected data on 6112 HF patients and compared the prognostic accuracy of MECKI score, HFSS, and SHFM at 2- and 4-year follow-up for the combined endpoint of cardiovascular death, urgent cardiac transplantation, or ventricular assist device implantation. Patients were followed up for a median of 3.67 years, and 931 cardiovascular deaths, 160 urgent heart transplantations, and 12 ventricular assist device implantations were recorded. At 2-year follow-up, the prognostic accuracy of MECKI score was significantly superior [area under the curve (AUC) 0.781] to that of SHFM (AUC 0.739) and HFSS (AUC 0.723), and this relationship was also confirmed at 4 years (AUC 0.764, 0.725, and 0.720, respectively).CONCLUSION: In this cohort, the prognostic accuracy of the MECKI score was superior to that of HFSS and SHFM at 2- and 4-year follow-up in HF patients in stable clinical condition. The MECKI score may be useful to improve resource allocation and patient outcome, but prospective evaluation is needed.",
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author = "Piergiuseppe Agostoni and Stefania Paolillo and Massimo Mapelli and Piero Gentile and Elisabetta Salvioni and Fabrizio Veglia and Alice Bonomi and Ugo Corr{\`a} and Rocco Lagioia and Giuseppe Limongelli and Gianfranco Sinagra and Gaia Cattadori and Scardovi, {Angela B} and Marco Metra and Valentina Carubelli and Domenico Scrutinio and Rosa Raimondo and Michele Emdin and Massimo Piepoli and Damiano Magr{\`i} and Gianfranco Parati and Sergio Caravita and Federica Re and Mariantonietta Cicoira and Chiara Min{\`a} and Michele Correale and Maria Frigerio and Maurizio Bussotti and Fabrizio Oliva and Elisa Battaia and Romualdo Belardinelli and Alessandro Mezzani and Luigi Pastormerlo and Marco Guazzi and Roberto Badagliacca and {Di Lenarda}, Andrea and Claudio Passino and Susanna Sciomer and Elena Zambon and Giuseppe Pacileo and Roberto Ricci and Anna Apostolo and Pietro Palermo and Mauro Contini and Francesco Clemenza and Giovanni Marchese and Paola Gargiulo and Simone Binno and Carlo Lombardi and Andrea Passantino and Filardi, {Pasquale Perrone}",
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TY - JOUR

T1 - Multiparametric prognostic scores in chronic heart failure with reduced ejection fraction

AU - Agostoni, Piergiuseppe

AU - Paolillo, Stefania

AU - Mapelli, Massimo

AU - Gentile, Piero

AU - Salvioni, Elisabetta

AU - Veglia, Fabrizio

AU - Bonomi, Alice

AU - Corrà, Ugo

AU - Lagioia, Rocco

AU - Limongelli, Giuseppe

AU - Sinagra, Gianfranco

AU - Cattadori, Gaia

AU - Scardovi, Angela B

AU - Metra, Marco

AU - Carubelli, Valentina

AU - Scrutinio, Domenico

AU - Raimondo, Rosa

AU - Emdin, Michele

AU - Piepoli, Massimo

AU - Magrì, Damiano

AU - Parati, Gianfranco

AU - Caravita, Sergio

AU - Re, Federica

AU - Cicoira, Mariantonietta

AU - Minà, Chiara

AU - Correale, Michele

AU - Frigerio, Maria

AU - Bussotti, Maurizio

AU - Oliva, Fabrizio

AU - Battaia, Elisa

AU - Belardinelli, Romualdo

AU - Mezzani, Alessandro

AU - Pastormerlo, Luigi

AU - Guazzi, Marco

AU - Badagliacca, Roberto

AU - Di Lenarda, Andrea

AU - Passino, Claudio

AU - Sciomer, Susanna

AU - Zambon, Elena

AU - Pacileo, Giuseppe

AU - Ricci, Roberto

AU - Apostolo, Anna

AU - Palermo, Pietro

AU - Contini, Mauro

AU - Clemenza, Francesco

AU - Marchese, Giovanni

AU - Gargiulo, Paola

AU - Binno, Simone

AU - Lombardi, Carlo

AU - Passantino, Andrea

AU - Filardi, Pasquale Perrone

N1 - © 2017 The Authors. European Journal of Heart Failure © 2017 European Society of Cardiology.

PY - 2018

Y1 - 2018

N2 - AIMS: Risk stratification in heart failure (HF) is crucial for clinical and therapeutic management. A multiparametric approach is the best method to stratify prognosis. In 2012, the Metabolic Exercise test data combined with Cardiac and Kidney Indexes (MECKI) score was proposed to assess the risk of cardiovascular mortality and urgent heart transplantation. The aim of the present study was to compare the prognostic accuracy of MECKI score to that of HF Survival Score (HFSS) and Seattle HF Model (SHFM) in a large, multicentre cohort of HF patients with reduced ejection fraction.METHODS AND RESULTS: We collected data on 6112 HF patients and compared the prognostic accuracy of MECKI score, HFSS, and SHFM at 2- and 4-year follow-up for the combined endpoint of cardiovascular death, urgent cardiac transplantation, or ventricular assist device implantation. Patients were followed up for a median of 3.67 years, and 931 cardiovascular deaths, 160 urgent heart transplantations, and 12 ventricular assist device implantations were recorded. At 2-year follow-up, the prognostic accuracy of MECKI score was significantly superior [area under the curve (AUC) 0.781] to that of SHFM (AUC 0.739) and HFSS (AUC 0.723), and this relationship was also confirmed at 4 years (AUC 0.764, 0.725, and 0.720, respectively).CONCLUSION: In this cohort, the prognostic accuracy of the MECKI score was superior to that of HFSS and SHFM at 2- and 4-year follow-up in HF patients in stable clinical condition. The MECKI score may be useful to improve resource allocation and patient outcome, but prospective evaluation is needed.

AB - AIMS: Risk stratification in heart failure (HF) is crucial for clinical and therapeutic management. A multiparametric approach is the best method to stratify prognosis. In 2012, the Metabolic Exercise test data combined with Cardiac and Kidney Indexes (MECKI) score was proposed to assess the risk of cardiovascular mortality and urgent heart transplantation. The aim of the present study was to compare the prognostic accuracy of MECKI score to that of HF Survival Score (HFSS) and Seattle HF Model (SHFM) in a large, multicentre cohort of HF patients with reduced ejection fraction.METHODS AND RESULTS: We collected data on 6112 HF patients and compared the prognostic accuracy of MECKI score, HFSS, and SHFM at 2- and 4-year follow-up for the combined endpoint of cardiovascular death, urgent cardiac transplantation, or ventricular assist device implantation. Patients were followed up for a median of 3.67 years, and 931 cardiovascular deaths, 160 urgent heart transplantations, and 12 ventricular assist device implantations were recorded. At 2-year follow-up, the prognostic accuracy of MECKI score was significantly superior [area under the curve (AUC) 0.781] to that of SHFM (AUC 0.739) and HFSS (AUC 0.723), and this relationship was also confirmed at 4 years (AUC 0.764, 0.725, and 0.720, respectively).CONCLUSION: In this cohort, the prognostic accuracy of the MECKI score was superior to that of HFSS and SHFM at 2- and 4-year follow-up in HF patients in stable clinical condition. The MECKI score may be useful to improve resource allocation and patient outcome, but prospective evaluation is needed.

KW - Journal Article

U2 - 10.1002/ejhf.989

DO - 10.1002/ejhf.989

M3 - Articolo

JO - European Journal of Heart Failure

JF - European Journal of Heart Failure

SN - 1388-9842

ER -