Multiple ADH genes are associated with upper aerodigestive cancers

Mia Hashibe, James D. McKay, Maria Paula Curado, Jose Carlos Oliveira, Sergio Koifman, Rosalina Koifman, David Zaridze, Oxana Shangina, Victor Wünsch-Filho, Jose Eluf-Neto, Jose Eduardo Levi, Elena Matos, Pagona Lagiou, Areti Lagiou, Simone Benhamou, Christine Bouchardy, Neonilia Szeszenia-Dabrowska, Ana Menezes, Marinel Mór Dall'Agnol, Franco MerlettiLorenzo Richiardi, Leticia Fernandez, Juan Lence, Renato Talamini, Luigi Barzan, Dana Mates, Ioan Nicolae Mates, Kristina Kjaerheim, Gary J. MacFarlane, Tatiana V. MacFarlane, Lorenzo Simonato, Cristina Canova, Ivana Holcátová, Antonio Agudo, Xavier Castellsagué, Ray Lowry, Vladimir Janout, Helena Kollarova, David I. Conway, Patricia A. McKinney, Ariana Znaor, Eleonora Fabianova, Vladimir Bencko, Jolanta Lissowska, Amelie Chabrier, Rayjean J. Hung, Valerie Gaborieau, Paolo Boffetta, Paul Brennan

Research output: Contribution to journalArticle

Abstract

Alcohol is an important risk factor for upper aerodigestive cancers and is principally metabolized by alcohol dehydrogenase (ADH) enzymes. We have investigated six ADH genetic variants in over 3,800 aerodigestive cancer cases and 5,200 controls from three individual studies. Gene variants rs1229984 (ADH1B) and rs1573496 (ADH7) were significantly protective against aerodigestive cancer in each individual study and overall (P = 10-10 and 10 -9, respectively). These effects became more apparent with increasing alcohol consumption (P for trend = 0.0002 and 0.065, respectively). Both gene effects were independent of each other, implying that multiple ADH genes may be involved in upper aerodigestive cancer etiology.

Original languageEnglish
Pages (from-to)707-709
Number of pages3
JournalNature Genetics
Volume40
Issue number6
DOIs
Publication statusPublished - Jun 2008

ASJC Scopus subject areas

  • Genetics(clinical)
  • Genetics

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    Hashibe, M., McKay, J. D., Curado, M. P., Oliveira, J. C., Koifman, S., Koifman, R., Zaridze, D., Shangina, O., Wünsch-Filho, V., Eluf-Neto, J., Levi, J. E., Matos, E., Lagiou, P., Lagiou, A., Benhamou, S., Bouchardy, C., Szeszenia-Dabrowska, N., Menezes, A., Dall'Agnol, M. M., ... Brennan, P. (2008). Multiple ADH genes are associated with upper aerodigestive cancers. Nature Genetics, 40(6), 707-709. https://doi.org/10.1038/ng.151