Multiple aphthoid syphilitic chancres of the oral cavity

Stefano Veraldi, L. Lunardon, M. C. Persico, C. Francia, S. Bottini

Research output: Contribution to journalArticlepeer-review


We describe the case of a 31-year-old man who was affected by three asymptomatic, aphthoid, syphilitic chancres of the oral cavity. These lesions were accompanied by right latero-cervical and chin lymphadenopathy. The infection was previously diagnosed as aphthous stomatitis. The search for Treponema pallidum by means of darkfield microscope examination was positive. The patient was successfully treated with oral erythromycin ethylsuccinate. To our knowledge, this is the first case of multiple aphthoid syphilitic chancres of the oral cavity reported in the literature. We suggest that all patients with a recent history of painless ulcers in the oral cavity, accompanied by regional lymphadenopathy in which the clinical diagnosis has not been confirmed, should undergo a darkfield microscope examination.

Original languageEnglish
Pages (from-to)486-487
Number of pages2
JournalInternational Journal of STD and AIDS
Issue number7
Publication statusPublished - Jul 2008


  • Aphthous stomatitis
  • Chancres
  • Oral cavity
  • Syphilis
  • Treponema pallidum

ASJC Scopus subject areas

  • Dermatology
  • Public Health, Environmental and Occupational Health
  • Microbiology (medical)
  • Immunology


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