Abstract
A 36-year-old woman with RAEB-t and severe bone marrow fibrosis undergoing autologous BMT, developed a histologically documented GVHD-like skin rash. Thereafter, autoimmune thyroiditis, autoimmune thrombocytopenic purpura and autoimmune hemolytic anemia and a lupus anti-coagulant (LAC) were diagnosed. The patient is still alive, symptom-free and in first complete remission (CR); however, all of the autoantibodies are still detectable, with the exception being the anti-erythrocyte antibody. The most outstanding feature of the present case is the polymorphism of the autoimmune events, in the absence of a coexisting systemic autoimmune disease. This patient has achieved long-term disease-free survival (DFS) in first CR despite high-risk MDS and the repeated immunosuppressant therapy required because of the complications described above; a GVL reaction somewhat similar to the autoimmune events may have contributed towards maintaining disease control.
| Original language | English |
|---|---|
| Pages (from-to) | 745-747 |
| Number of pages | 3 |
| Journal | Bone Marrow Transplantation |
| Volume | 19 |
| Issue number | 7 |
| Publication status | Published - Apr 1 1997 |
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Keywords
- AutoBMT
- Autoimmune diseases
- Graft-versus-host disease
- Myelodysplastic syndrome
ASJC Scopus subject areas
- Hematology
- Transplantation
Cite this
Multiple autoimmune events after autologous bone marrow transplantation. / Lambertenghi Deliliers, G.; Annaloro, C.; Della Volpe, A.; Oriani, A.; Pozzoli, E.; Soligo, D.
In: Bone Marrow Transplantation, Vol. 19, No. 7, 01.04.1997, p. 745-747.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Multiple autoimmune events after autologous bone marrow transplantation
AU - Lambertenghi Deliliers, G.
AU - Annaloro, C.
AU - Della Volpe, A.
AU - Oriani, A.
AU - Pozzoli, E.
AU - Soligo, D.
PY - 1997/4/1
Y1 - 1997/4/1
N2 - A 36-year-old woman with RAEB-t and severe bone marrow fibrosis undergoing autologous BMT, developed a histologically documented GVHD-like skin rash. Thereafter, autoimmune thyroiditis, autoimmune thrombocytopenic purpura and autoimmune hemolytic anemia and a lupus anti-coagulant (LAC) were diagnosed. The patient is still alive, symptom-free and in first complete remission (CR); however, all of the autoantibodies are still detectable, with the exception being the anti-erythrocyte antibody. The most outstanding feature of the present case is the polymorphism of the autoimmune events, in the absence of a coexisting systemic autoimmune disease. This patient has achieved long-term disease-free survival (DFS) in first CR despite high-risk MDS and the repeated immunosuppressant therapy required because of the complications described above; a GVL reaction somewhat similar to the autoimmune events may have contributed towards maintaining disease control.
AB - A 36-year-old woman with RAEB-t and severe bone marrow fibrosis undergoing autologous BMT, developed a histologically documented GVHD-like skin rash. Thereafter, autoimmune thyroiditis, autoimmune thrombocytopenic purpura and autoimmune hemolytic anemia and a lupus anti-coagulant (LAC) were diagnosed. The patient is still alive, symptom-free and in first complete remission (CR); however, all of the autoantibodies are still detectable, with the exception being the anti-erythrocyte antibody. The most outstanding feature of the present case is the polymorphism of the autoimmune events, in the absence of a coexisting systemic autoimmune disease. This patient has achieved long-term disease-free survival (DFS) in first CR despite high-risk MDS and the repeated immunosuppressant therapy required because of the complications described above; a GVL reaction somewhat similar to the autoimmune events may have contributed towards maintaining disease control.
KW - AutoBMT
KW - Autoimmune diseases
KW - Graft-versus-host disease
KW - Myelodysplastic syndrome
UR - http://www.scopus.com/inward/record.url?scp=0030969813&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0030969813&partnerID=8YFLogxK
M3 - Article
C2 - 9156254
AN - SCOPUS:0030969813
VL - 19
SP - 745
EP - 747
JO - Bone Marrow Transplantation
JF - Bone Marrow Transplantation
SN - 0268-3369
IS - 7
ER -