Multiple autoimmune events after autologous bone marrow transplantation

G. Lambertenghi Deliliers, C. Annaloro, A. Della Volpe, A. Oriani, E. Pozzoli, D. Soligo

Research output: Contribution to journalArticlepeer-review

Abstract

A 36-year-old woman with RAEB-t and severe bone marrow fibrosis undergoing autologous BMT, developed a histologically documented GVHD-like skin rash. Thereafter, autoimmune thyroiditis, autoimmune thrombocytopenic purpura and autoimmune hemolytic anemia and a lupus anti-coagulant (LAC) were diagnosed. The patient is still alive, symptom-free and in first complete remission (CR); however, all of the autoantibodies are still detectable, with the exception being the anti-erythrocyte antibody. The most outstanding feature of the present case is the polymorphism of the autoimmune events, in the absence of a coexisting systemic autoimmune disease. This patient has achieved long-term disease-free survival (DFS) in first CR despite high-risk MDS and the repeated immunosuppressant therapy required because of the complications described above; a GVL reaction somewhat similar to the autoimmune events may have contributed towards maintaining disease control.

Original languageEnglish
Pages (from-to)745-747
Number of pages3
JournalBone Marrow Transplantation
Volume19
Issue number7
Publication statusPublished - Apr 1 1997

Keywords

  • AutoBMT
  • Autoimmune diseases
  • Graft-versus-host disease
  • Myelodysplastic syndrome

ASJC Scopus subject areas

  • Hematology
  • Transplantation

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