Multiple autoimmune events after autologous bone marrow transplantation

G. Lambertenghi Deliliers, C. Annaloro, A. Della Volpe, A. Oriani, E. Pozzoli, D. Soligo

Research output: Contribution to journalArticle

Abstract

A 36-year-old woman with RAEB-t and severe bone marrow fibrosis undergoing autologous BMT, developed a histologically documented GVHD-like skin rash. Thereafter, autoimmune thyroiditis, autoimmune thrombocytopenic purpura and autoimmune hemolytic anemia and a lupus anti-coagulant (LAC) were diagnosed. The patient is still alive, symptom-free and in first complete remission (CR); however, all of the autoantibodies are still detectable, with the exception being the anti-erythrocyte antibody. The most outstanding feature of the present case is the polymorphism of the autoimmune events, in the absence of a coexisting systemic autoimmune disease. This patient has achieved long-term disease-free survival (DFS) in first CR despite high-risk MDS and the repeated immunosuppressant therapy required because of the complications described above; a GVL reaction somewhat similar to the autoimmune events may have contributed towards maintaining disease control.

Original languageEnglish
Pages (from-to)745-747
Number of pages3
JournalBone Marrow Transplantation
Volume19
Issue number7
Publication statusPublished - Apr 1 1997

Fingerprint

Autologous Transplantation
Bone Marrow Transplantation
Refractory Anemia with Excess of Blasts
Autoimmune Thyroiditis
Autoimmune Hemolytic Anemia
Coagulants
Primary Myelofibrosis
Idiopathic Thrombocytopenic Purpura
Immunosuppressive Agents
Exanthema
Autoantibodies
Autoimmune Diseases
Disease-Free Survival
Anti-Idiotypic Antibodies
Erythrocytes
Therapeutics

Keywords

  • AutoBMT
  • Autoimmune diseases
  • Graft-versus-host disease
  • Myelodysplastic syndrome

ASJC Scopus subject areas

  • Hematology
  • Transplantation

Cite this

Lambertenghi Deliliers, G., Annaloro, C., Della Volpe, A., Oriani, A., Pozzoli, E., & Soligo, D. (1997). Multiple autoimmune events after autologous bone marrow transplantation. Bone Marrow Transplantation, 19(7), 745-747.

Multiple autoimmune events after autologous bone marrow transplantation. / Lambertenghi Deliliers, G.; Annaloro, C.; Della Volpe, A.; Oriani, A.; Pozzoli, E.; Soligo, D.

In: Bone Marrow Transplantation, Vol. 19, No. 7, 01.04.1997, p. 745-747.

Research output: Contribution to journalArticle

Lambertenghi Deliliers, G, Annaloro, C, Della Volpe, A, Oriani, A, Pozzoli, E & Soligo, D 1997, 'Multiple autoimmune events after autologous bone marrow transplantation', Bone Marrow Transplantation, vol. 19, no. 7, pp. 745-747.
Lambertenghi Deliliers G, Annaloro C, Della Volpe A, Oriani A, Pozzoli E, Soligo D. Multiple autoimmune events after autologous bone marrow transplantation. Bone Marrow Transplantation. 1997 Apr 1;19(7):745-747.
Lambertenghi Deliliers, G. ; Annaloro, C. ; Della Volpe, A. ; Oriani, A. ; Pozzoli, E. ; Soligo, D. / Multiple autoimmune events after autologous bone marrow transplantation. In: Bone Marrow Transplantation. 1997 ; Vol. 19, No. 7. pp. 745-747.
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