Multiple cause-of-death data among people with AIDS in Italy: A nationwide cross-sectional study

Enrico Grande, Antonella Zucchetto, Barbara Suligoi, Francesco Grippo, Marilena Pappagallo, Saverio Virdone, Laura Camoni, Martina Taborelli, Vincenza Regine, Diego Serraino, Luisa Frova

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Background: Multiple cause-of-death (MCOD) data allow analyzing the contribution to mortality of conditions reported on the death certificate that are not selected as the underlying cause of death. Using MCOD data, this study aimed to fully describe the cause-specific mortality of people with AIDS (PWA) compared to people without AIDS. Methods: We conducted a nationwide investigation based on death certificates of 2,515 Italian PWA and 123,224 people without AIDS who had died between 2006 and 2010. The conditions most frequently associated with PWA mortality, compared to people without AIDS, were identified using an age-standardized proportion ratio (ASPR) calculated as the ratio between the age-standardized proportion of a specific cause among PWA and the same proportion among people without AIDS. Results: The most frequently reported conditions at death among PWA were infectious/parasitic diseases (52%), digestive (36%), respiratory (33%), and circulatory (32%) system diseases, and neoplasms (29%). All AIDS-defining conditions resulted highly associated (ASPR significantly greater than unity) with PWA deaths. Significant associations also emerged for leishmaniasis (ASPR = 188.0), encephalitis/myelitis/encephalomyelitis (ASPR = 14.3), dementia (ASPR = 13.1), chronic viral hepatitis (ASPR = 13.1), liver fibrosis/cirrhosis (ASPR = 4.4), pneumonia (ASPR = 4.4), anal (ASPR = 12.1) and liver (ASPR = 1.9) cancers, and Hodgkin's disease (ASPR = 3.1). Conclusions: Study findings identified the contribution of several non-AIDS-defining conditions on PWA mortality, emphasizing the need of preventive public health interventions targeting this population.

Original languageEnglish
Article number19
JournalPopulation Health Metrics
Volume15
Issue number1
DOIs
Publication statusPublished - May 18 2017

Fingerprint

Italy
Cause of Death
Acquired Immunodeficiency Syndrome
Cross-Sectional Studies
Death Certificates
Mortality
Liver Cirrhosis
Myelitis
Encephalomyelitis
Parasitic Diseases
Leishmaniasis
Encephalitis
Chronic Hepatitis
Cardiovascular System
Hodgkin Disease
Communicable Diseases
Dementia
Neoplasms
Pneumonia
Public Health

Keywords

  • Cause-specific mortality
  • HIV/AIDS
  • Italy
  • Multiple causes of death

ASJC Scopus subject areas

  • Epidemiology
  • Public Health, Environmental and Occupational Health

Cite this

Multiple cause-of-death data among people with AIDS in Italy : A nationwide cross-sectional study. / Grande, Enrico; Zucchetto, Antonella; Suligoi, Barbara; Grippo, Francesco; Pappagallo, Marilena; Virdone, Saverio; Camoni, Laura; Taborelli, Martina; Regine, Vincenza; Serraino, Diego; Frova, Luisa.

In: Population Health Metrics, Vol. 15, No. 1, 19, 18.05.2017.

Research output: Contribution to journalArticle

Grande, E, Zucchetto, A, Suligoi, B, Grippo, F, Pappagallo, M, Virdone, S, Camoni, L, Taborelli, M, Regine, V, Serraino, D & Frova, L 2017, 'Multiple cause-of-death data among people with AIDS in Italy: A nationwide cross-sectional study', Population Health Metrics, vol. 15, no. 1, 19. https://doi.org/10.1186/s12963-017-0135-3
Grande, Enrico ; Zucchetto, Antonella ; Suligoi, Barbara ; Grippo, Francesco ; Pappagallo, Marilena ; Virdone, Saverio ; Camoni, Laura ; Taborelli, Martina ; Regine, Vincenza ; Serraino, Diego ; Frova, Luisa. / Multiple cause-of-death data among people with AIDS in Italy : A nationwide cross-sectional study. In: Population Health Metrics. 2017 ; Vol. 15, No. 1.
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abstract = "Background: Multiple cause-of-death (MCOD) data allow analyzing the contribution to mortality of conditions reported on the death certificate that are not selected as the underlying cause of death. Using MCOD data, this study aimed to fully describe the cause-specific mortality of people with AIDS (PWA) compared to people without AIDS. Methods: We conducted a nationwide investigation based on death certificates of 2,515 Italian PWA and 123,224 people without AIDS who had died between 2006 and 2010. The conditions most frequently associated with PWA mortality, compared to people without AIDS, were identified using an age-standardized proportion ratio (ASPR) calculated as the ratio between the age-standardized proportion of a specific cause among PWA and the same proportion among people without AIDS. Results: The most frequently reported conditions at death among PWA were infectious/parasitic diseases (52{\%}), digestive (36{\%}), respiratory (33{\%}), and circulatory (32{\%}) system diseases, and neoplasms (29{\%}). All AIDS-defining conditions resulted highly associated (ASPR significantly greater than unity) with PWA deaths. Significant associations also emerged for leishmaniasis (ASPR = 188.0), encephalitis/myelitis/encephalomyelitis (ASPR = 14.3), dementia (ASPR = 13.1), chronic viral hepatitis (ASPR = 13.1), liver fibrosis/cirrhosis (ASPR = 4.4), pneumonia (ASPR = 4.4), anal (ASPR = 12.1) and liver (ASPR = 1.9) cancers, and Hodgkin's disease (ASPR = 3.1). Conclusions: Study findings identified the contribution of several non-AIDS-defining conditions on PWA mortality, emphasizing the need of preventive public health interventions targeting this population.",
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AU - Grande, Enrico

AU - Zucchetto, Antonella

AU - Suligoi, Barbara

AU - Grippo, Francesco

AU - Pappagallo, Marilena

AU - Virdone, Saverio

AU - Camoni, Laura

AU - Taborelli, Martina

AU - Regine, Vincenza

AU - Serraino, Diego

AU - Frova, Luisa

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