Abstract
Numerical and structural chromosome aberrations were found in cell plaque metaphases from 9 of 14 patients with Peyronie's disease. In two cases there was evidence of clonal evolution for some of the chromosomal aberrations observed. The Y chromosome was the most frequently involved in numerical changes. Four of 9 cases with abnormal karyotype showed more than one abnormal, cytogenetically unrelated clone. Our findings suggest the possibility of a multiclonal origin for this benign tumor, and confirm the presence of chromosome instability in this cell growth disorder.
| Original language | English |
|---|---|
| Pages (from-to) | 181-185 |
| Number of pages | 5 |
| Journal | Cancer Genetics and Cytogenetics |
| Volume | 52 |
| Issue number | 2 |
| DOIs | |
| Publication status | Published - 1991 |
Fingerprint
ASJC Scopus subject areas
- Cancer Research
- Genetics
- Molecular Biology
Cite this
Multiple clonal chromosome abnormalities in Peyronie's disease. / Guerneri, S.; Stioui, S.; Mantovani, F.; Austoni, E.; Simoni, G.
In: Cancer Genetics and Cytogenetics, Vol. 52, No. 2, 1991, p. 181-185.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Multiple clonal chromosome abnormalities in Peyronie's disease
AU - Guerneri, S.
AU - Stioui, S.
AU - Mantovani, F.
AU - Austoni, E.
AU - Simoni, G.
PY - 1991
Y1 - 1991
N2 - Numerical and structural chromosome aberrations were found in cell plaque metaphases from 9 of 14 patients with Peyronie's disease. In two cases there was evidence of clonal evolution for some of the chromosomal aberrations observed. The Y chromosome was the most frequently involved in numerical changes. Four of 9 cases with abnormal karyotype showed more than one abnormal, cytogenetically unrelated clone. Our findings suggest the possibility of a multiclonal origin for this benign tumor, and confirm the presence of chromosome instability in this cell growth disorder.
AB - Numerical and structural chromosome aberrations were found in cell plaque metaphases from 9 of 14 patients with Peyronie's disease. In two cases there was evidence of clonal evolution for some of the chromosomal aberrations observed. The Y chromosome was the most frequently involved in numerical changes. Four of 9 cases with abnormal karyotype showed more than one abnormal, cytogenetically unrelated clone. Our findings suggest the possibility of a multiclonal origin for this benign tumor, and confirm the presence of chromosome instability in this cell growth disorder.
UR - http://www.scopus.com/inward/record.url?scp=0025764469&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0025764469&partnerID=8YFLogxK
U2 - 10.1016/0165-4608(91)90461-3
DO - 10.1016/0165-4608(91)90461-3
M3 - Article
C2 - 2021920
AN - SCOPUS:0025764469
VL - 52
SP - 181
EP - 185
JO - Cancer Genetics and Cytogenetics
JF - Cancer Genetics and Cytogenetics
SN - 0165-4608
IS - 2
ER -