Abstract
Numerical and structural chromosome aberrations were found in cell plaque metaphases from 9 of 14 patients with Peyronie's disease. In two cases there was evidence of clonal evolution for some of the chromosomal aberrations observed. The Y chromosome was the most frequently involved in numerical changes. Four of 9 cases with abnormal karyotype showed more than one abnormal, cytogenetically unrelated clone. Our findings suggest the possibility of a multiclonal origin for this benign tumor, and confirm the presence of chromosome instability in this cell growth disorder.
Original language | English |
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Pages (from-to) | 181-185 |
Number of pages | 5 |
Journal | Cancer Genetics and Cytogenetics |
Volume | 52 |
Issue number | 2 |
DOIs | |
Publication status | Published - 1991 |
ASJC Scopus subject areas
- Cancer Research
- Genetics
- Molecular Biology