Multiple clonal chromosome abnormalities in Peyronie's disease

S. Guerneri, S. Stioui, F. Mantovani, E. Austoni, G. Simoni

Research output: Contribution to journalArticlepeer-review

Abstract

Numerical and structural chromosome aberrations were found in cell plaque metaphases from 9 of 14 patients with Peyronie's disease. In two cases there was evidence of clonal evolution for some of the chromosomal aberrations observed. The Y chromosome was the most frequently involved in numerical changes. Four of 9 cases with abnormal karyotype showed more than one abnormal, cytogenetically unrelated clone. Our findings suggest the possibility of a multiclonal origin for this benign tumor, and confirm the presence of chromosome instability in this cell growth disorder.

Original languageEnglish
Pages (from-to)181-185
Number of pages5
JournalCancer Genetics and Cytogenetics
Volume52
Issue number2
DOIs
Publication statusPublished - 1991

ASJC Scopus subject areas

  • Cancer Research
  • Genetics
  • Molecular Biology

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