Multiple clonal chromosome abnormalities in Peyronie's disease

S. Guerneri; S. Stioui; F. Mantovani; E. Austoni; G. Simoni

doi:10.1016/0165-4608(91)90461-3

Multiple clonal chromosome abnormalities in Peyronie's disease

S. Guerneri, S. Stioui, F. Mantovani, E. Austoni, G. Simoni

Fondazione IRCCS Ca' Granda- Ospedale Maggiore Policlinico

Research output: Contribution to journal › Article › peer-review

Abstract

Numerical and structural chromosome aberrations were found in cell plaque metaphases from 9 of 14 patients with Peyronie's disease. In two cases there was evidence of clonal evolution for some of the chromosomal aberrations observed. The Y chromosome was the most frequently involved in numerical changes. Four of 9 cases with abnormal karyotype showed more than one abnormal, cytogenetically unrelated clone. Our findings suggest the possibility of a multiclonal origin for this benign tumor, and confirm the presence of chromosome instability in this cell growth disorder.

Original language	English
Pages (from-to)	181-185
Number of pages	5
Journal	Cancer Genetics and Cytogenetics
Volume	52
Issue number	2
DOIs	https://doi.org/10.1016/0165-4608(91)90461-3
Publication status	Published - 1991

ASJC Scopus subject areas

Cancer Research
Genetics
Molecular Biology

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author = "S. Guerneri and S. Stioui and F. Mantovani and E. Austoni and G. Simoni",

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AU - Simoni, G.

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AB - Numerical and structural chromosome aberrations were found in cell plaque metaphases from 9 of 14 patients with Peyronie's disease. In two cases there was evidence of clonal evolution for some of the chromosomal aberrations observed. The Y chromosome was the most frequently involved in numerical changes. Four of 9 cases with abnormal karyotype showed more than one abnormal, cytogenetically unrelated clone. Our findings suggest the possibility of a multiclonal origin for this benign tumor, and confirm the presence of chromosome instability in this cell growth disorder.

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