Multiple clonal chromosome abnormalities in Peyronie's disease

S. Guerneri, S. Stioui, F. Mantovani, E. Austoni, G. Simoni

Research output: Contribution to journalArticle

Abstract

Numerical and structural chromosome aberrations were found in cell plaque metaphases from 9 of 14 patients with Peyronie's disease. In two cases there was evidence of clonal evolution for some of the chromosomal aberrations observed. The Y chromosome was the most frequently involved in numerical changes. Four of 9 cases with abnormal karyotype showed more than one abnormal, cytogenetically unrelated clone. Our findings suggest the possibility of a multiclonal origin for this benign tumor, and confirm the presence of chromosome instability in this cell growth disorder.

Original languageEnglish
Pages (from-to)181-185
Number of pages5
JournalCancer Genetics and Cytogenetics
Volume52
Issue number2
DOIs
Publication statusPublished - 1991

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Penile Induration
Chromosome Aberrations
Growth Disorders
Clonal Evolution
Abnormal Karyotype
Chromosomal Instability
Y Chromosome
Metaphase
Clone Cells
Neoplasms

ASJC Scopus subject areas

  • Cancer Research
  • Genetics
  • Molecular Biology

Cite this

Multiple clonal chromosome abnormalities in Peyronie's disease. / Guerneri, S.; Stioui, S.; Mantovani, F.; Austoni, E.; Simoni, G.

In: Cancer Genetics and Cytogenetics, Vol. 52, No. 2, 1991, p. 181-185.

Research output: Contribution to journalArticle

Guerneri, S. ; Stioui, S. ; Mantovani, F. ; Austoni, E. ; Simoni, G. / Multiple clonal chromosome abnormalities in Peyronie's disease. In: Cancer Genetics and Cytogenetics. 1991 ; Vol. 52, No. 2. pp. 181-185.
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