TY - JOUR
T1 - Multiple cutaneous granular cell tumors, joint hypermobility and mild facial dysmorphism in a child
AU - Muscardin, Luca M.
AU - Paradisi, Mauro
AU - Provini, Alessia
AU - Cota, Carlo
AU - Marzetti, Gianfranco
PY - 2006/7
Y1 - 2006/7
N2 - Background: The association of multiple cutaneous granular tumors with systemic defects is extremely rare. To date, 14 cases have been described. Case report: A 14-year-old boy presented multiple nodular lesions on his arms and legs; facial dysmorphism and joint hypermobility were also present. Histopathologic examination of two nodules showed granular cell tumors. We review the literature regarding multiple granular cell cutaneous tumors in children with associated somatic defects and genetic syndromes. Conclusions: The combination of multiple cutaneous granular tumors with alterations in other organs is not only fortuitous, justifying the proposal of a distinct syndrome, termed "Bakos's syndrome" after the author who first described this association. The relation with neurofibromatosis type 1 is discussed, and an association is suggested with the range of variants of this syndrome.
AB - Background: The association of multiple cutaneous granular tumors with systemic defects is extremely rare. To date, 14 cases have been described. Case report: A 14-year-old boy presented multiple nodular lesions on his arms and legs; facial dysmorphism and joint hypermobility were also present. Histopathologic examination of two nodules showed granular cell tumors. We review the literature regarding multiple granular cell cutaneous tumors in children with associated somatic defects and genetic syndromes. Conclusions: The combination of multiple cutaneous granular tumors with alterations in other organs is not only fortuitous, justifying the proposal of a distinct syndrome, termed "Bakos's syndrome" after the author who first described this association. The relation with neurofibromatosis type 1 is discussed, and an association is suggested with the range of variants of this syndrome.
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U2 - 10.1111/j.1365-4632.2004.02476.x
DO - 10.1111/j.1365-4632.2004.02476.x
M3 - Article
C2 - 16863524
AN - SCOPUS:33745629058
VL - 45
SP - 847
EP - 850
JO - International Journal of Dermatology
JF - International Journal of Dermatology
SN - 0011-9059
IS - 7
ER -